Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UCHL1 | P09936 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 3/20 | 0.32 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.32 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.32 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | JAK1 | P23458 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2499313 | 0.88 | UCHL1 (0.39) | UCHL1MEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL5352509 | 0.85 | UCHL1 (0.42) | UCHL1NR1H2CYP1A2POLBCYP3A4 | |
| SCHEMBL30170063 | 0.84 | P2RX3 (0.39) | UCHL1MEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL5068851 | 0.84 | AGTR2 (0.34) | CTSKAVPR2 | |
| SCHEMBL2501733 | 0.83 | UCHL1 (0.41) | UCHL1NR1H2CYP1A2POLBCYP3A4 | |
| SCHEMBL2502694 | 0.81 | UCHL1 (0.40) | UCHL1NR1H2CYP1A2POLBCYP3A4 | |
| SCHEMBL2495165 | 0.81 | UCHL1 (0.40) | UCHL1NR1H2CYP1A2POLBCYP3A4 | |
| SCHEMBL5359255 | 0.81 | UCHL1 (0.54) | UCHL1NR1H2CYP1A2POLBCYP3A4 | |
| SCHEMBL2500844 | 0.79 | UCHL1 (0.39) | UCHL1MEN1KMT2ANR1H2CYP1A2 | |
| SCHEMBL30955441 | 0.79 | UCHL1 (0.43) | UCHL1NR1H2CYP1A2POLBCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8030499-B2 | 1,3-dihydro-2H-indole-2-one compound and pyrrolidine-2-one compound fused with aromatic heterocycle | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2011-10-04 | — | — | US | disclosed |