Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 2/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.33 |
| ▸ | CDK2 | P24941 | 2/20 | 0.33 |
| ▸ | CDK9 | P50750 | 2/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 7/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | CTSK | P43235 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | CASP1 | P29466 | 1/20 | 0.30 |
| ▸ | CASP7 | P55210 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24944975 | 0.87 | LRRK2 (0.36) | CCNT1CCNA2CDK2CDK9LRRK2 | |
| SCHEMBL29173373 | 0.85 | ALDH1A1 (0.41) | CCNT1CCNA2CDK2CDK9LRRK2 | |
| SCHEMBL30206005 | 0.85 | ALDH1A1 (0.41) | CCNT1CCNA2CDK2CDK9LRRK2 | |
| SCHEMBL24943793 | 0.79 | LRRK2 (0.32) | LRRK2 | |
| SCHEMBL24944171 | 0.78 | FLT3 (0.40) | CDK2LRRK2 | |
| SCHEMBL30205483 | 0.77 | EML4 (0.36) | CCNA2CDK2PIK3CA | |
| SCHEMBL24944436 | 0.77 | EML4 (0.36) | CCNA2CDK2PIK3CA | |
| SCHEMBL29173387 | 0.76 | LRRK2 (0.40) | CCNT1CCNA2CDK2CDK9LRRK2 | |
| SCHEMBL30206049 | 0.76 | LRRK2 (0.40) | CCNT1CCNA2CDK2CDK9LRRK2 | |
| SCHEMBL31577321 | 0.75 | LRRK2 (0.33) | LRRK2ALDH1A1RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023001794-A1 | SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2023-01-26 | — | — | WO | disclosed |