Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 4/20 | 0.34 |
| ▸ | EML4 | Q9HC35 | 3/20 | 0.34 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 4/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 3/20 | 0.32 |
| ▸ | CDC7 | O00311 | 1/20 | 0.31 |
| ▸ | PLK4 | O00444 | 1/20 | 0.31 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.31 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.31 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.31 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Formic Acid SCHEMBL30205522 | 0.97 | AURKA (0.33) | ALKEML4RPS6KB1AURKAAURKB | |
| Formic Acid SCHEMBL29173295 | 0.97 | AURKA (0.33) | ALKEML4RPS6KB1AURKAAURKB | |
| SCHEMBL30205499 | 0.91 | TYK2 (0.37) | ALKEML4SYKTYK2LRRK2 | |
| SCHEMBL24944982 | 0.91 | TYK2 (0.37) | ALKEML4SYKTYK2LRRK2 | |
| SCHEMBL29173658 | 0.91 | BUB1 (0.34) | SYKHDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL24943808 | 0.89 | EML4 (0.33) | ALKEML4RPS6KB1AURKAAURKB | |
| SCHEMBL30205492 | 0.89 | EML4 (0.33) | ALKEML4RPS6KB1AURKAAURKB | |
| SCHEMBL24943828 | 0.87 | CDK2 (0.37) | AURKAAURKBSYKPDPK1JAK2 | |
| SCHEMBL24944179 | 0.86 | LRRK2 (0.33) | ALKEML4SYKRETROS1 | |
| SCHEMBL30205755 | 0.86 | LRRK2 (0.33) | ALKEML4SYKRETROS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023001794-A1 | SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2023-01-26 | — | — | WO | disclosed |