Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.30 |
| ▸ | NQO2 | P16083 | 1/20 | 0.30 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.30 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24944492 | 0.87 | MAP2K2 (0.34) | SYKABCB11NQO2MAP2K2MAP2K1 | |
| SCHEMBL24944991 | 0.86 | SYK (0.30) | SYK | |
| SCHEMBL24944442 | 0.85 | RET (0.37) | SYKNQO2MAP2K2MAP2K1 | |
| SCHEMBL24944987 | 0.84 | MAP2K2 (0.41) | SYKABCB11NQO2MAP2K2MAP2K1 | |
| SCHEMBL30205495 | 0.83 | LRRK2 (0.36) | SYK | |
| SCHEMBL24944784 | 0.83 | LRRK2 (0.36) | SYK | |
| SCHEMBL29173320 | 0.83 | GPR119 (0.35) | ABCB11NQO2MAP2K2MAP2K1 | |
| SCHEMBL24944164 | 0.82 | RET (0.36) | SYKNQO2MAP2K2MAP2K1 | |
| SCHEMBL24944988 | 0.82 | ABCB11 (0.33) | SYKABCB11NQO2MAP2K2MAP2K1 | |
| SCHEMBL24943828 | 0.82 | CDK2 (0.37) | SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023001794-A1 | SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2023-01-26 | — | — | WO | disclosed |