Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K2 | P36507 | 2/20 | 0.41 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.41 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.33 |
| ▸ | NQO2 | P16083 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | PLK1 | P53350 | 1/20 | 0.31 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.31 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.31 |
| ▸ | PLK2 | Q9NYY3 | 1/20 | 0.31 |
| ▸ | IKBKB | O14920 | 1/20 | 0.30 |
| ▸ | RET | P07949 | 1/20 | 0.30 |
| ▸ | ROS1 | P08922 | 1/20 | 0.30 |
| ▸ | FLT3 | P36888 | 1/20 | 0.30 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.30 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.30 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24944492 | 0.90 | MAP2K2 (0.34) | MAP2K2MAP2K1ABCB11NQO2SYK | |
| SCHEMBL29173320 | 0.87 | GPR119 (0.35) | MAP2K2MAP2K1ABCB11NQO2CCNA2 | |
| SCHEMBL24944988 | 0.86 | ABCB11 (0.33) | MAP2K2MAP2K1ABCB11NQO2SYK | |
| SCHEMBL24944491 | 0.85 | ABCB11 (0.32) | MAP2K2MAP2K1ABCB11NQO2SYK | |
| SCHEMBL24944992 | 0.84 | SYK (0.33) | MAP2K2MAP2K1ABCB11NQO2SYK | |
| SCHEMBL30205517 | 0.83 | MAPK9 (0.48) | MAP2K2SYKAURKACDK2PLK1 | |
| SCHEMBL24944367 | 0.83 | MAPK9 (0.48) | MAP2K2SYKAURKACDK2PLK1 | |
| SCHEMBL24944786 | 0.83 | IKBKE (0.38) | MAP2K2MAP2K1ABCB11NQO2RET | |
| SCHEMBL24944783 | 0.82 | LRRK2 (0.41) | SYKAURKARETROS1FLT3 | |
| SCHEMBL24944998 | 0.80 | EML4 (0.35) | SYKRETROS1FLT3EML4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023001794-A1 | SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2023-01-26 | — | — | WO | disclosed |