Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNK3 | O14649 | 2/20 | 0.81 |
| ▸ | LMNA | P02545 | 1/20 | 0.81 |
| ▸ | MAPT | P10636 | 1/20 | 0.78 |
| ▸ | MEN1 | O00255 | 6/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.72 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.72 |
| ▸ | HTT | P42858 | 1/20 | 0.72 |
| ▸ | RAB9A | P51151 | 1/20 | 0.72 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.71 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.71 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.66 |
| ▸ | RHOC | P08134 | 1/20 | 0.64 |
| ▸ | RHOA | P61586 | 1/20 | 0.64 |
| ▸ | POLB | P06746 | 2/20 | 0.63 |
| ▸ | CASP6 | P55212 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.61 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.61 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.61 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2106595 | 0.99 | KCNK3 (0.79) | KCNK3LMNAMAPTMEN1KMT2A | |
| SCHEMBL2493221 | 0.94 | MAPT (0.88) | KCNK3LMNAMAPTMEN1KMT2A | |
| SCHEMBL1534374 | 0.91 | RHOC (0.71) | KCNK3LMNAMAPTMEN1KMT2A | |
| SCHEMBL4286068 | 0.91 | MAPT (0.94) | KCNK3LMNAMAPTMEN1KMT2A | |
| SCHEMBL23070449 | 0.90 | NR1H4 (0.72) | KCNK3LMNAMAPTMEN1KMT2A | |
| SCHEMBL4517587 | 0.89 | LMNA (1.00) | KCNK3LMNAMAPTMEN1KMT2A | |
| SCHEMBL30739929 | 0.89 | LMNA (1.00) | KCNK3LMNAMAPTMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL2104426 | 0.88 | NR1H4 (0.70) | KCNK3LMNAMAPTMEN1KMT2A | |
| SCHEMBL15094033 | 0.88 | MAPT (0.78) | KCNK3LMNAMAPTMEN1KMT2A | |
| SCHEMBL4656855 | 0.88 | MAPT (0.78) | KCNK3LMNAMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021038419-A1 | KINASE INHIBITORS AND METHODS OF SYNTHESIS AND TREATMENT | INSILICO MEDICINE IP LIMITED (CN) | 2021-03-04 | — | — | WO | disclosed |
| WO-2021038419-A1 | KINASE INHIBITORS AND METHODS OF SYNTHESIS AND TREATMENT | INSILICO MEDICINE IP LIMITED (CN) | 2021-03-04 | — | — | WO | disclosed |
| US-10604493-B2 | Compositions, methods of use, and methods of treatment | UNIVERSITY OF SOUTH FLORIDA (US) | 2020-03-31 | — | — | US | disclosed |
| US-20170088524-A1 | Compositions, Methods of Use, And Methods of Treatment | UNIVERSITY OF SOUTH FLORIDA | 2017-03-30 | — | — | US | disclosed |
| US-9556131-B2 | Compositions, methods of use, and methods of treatment | UNIVERSITY OF SOUTH FLORIDA (US) | 2017-01-31 | — | — | US | disclosed |
| US-20140378516-A1 | COMPOSITIONS, METHODS OF USE, AND METHODS OF TREATMENT | UNIVERSITY OF SOUTH FLORIDA | 2014-12-25 | — | — | US | disclosed |
| EP-2800568-A1 | COMPOSITIONS, METHODS OF USE, AND METHODS OF TREATMENT | University Of South Florida (US) | 2014-11-12 | — | — | EP | disclosed |
| WO-2013103760-A1 | COMPOSITIONS, METHODS OF USE, AND METHODS OF TREATMENT | UNIVERSITY OF SOUTH FLORIDA (US) | 2013-07-11 | — | — | WO | disclosed |
| US-8030487-B2 | 2-amino—5-substituted pyrimidine inhibitors | TARGEGEN, INC. (US) | 2011-10-04 | — | — | US | disclosed |
| US-8030487-B2 | 2-amino—5-substituted pyrimidine inhibitors | TARGEGEN, INC. (US) | 2011-10-04 | — | — | US | disclosed |
| US-8030487-B2 | 2-amino—5-substituted pyrimidine inhibitors | TARGEGEN, INC. (US) | 2011-10-04 | — | — | US | disclosed |
| US-20080027070-A1 | 2-AMINO--5-SUBSTITUTED PYRIMIDINE INHIBITORS | TARGEGEN, INC. (US) | 2008-01-31 | — | — | US | disclosed |
| US-20080027070-A1 | 2-AMINO--5-SUBSTITUTED PYRIMIDINE INHIBITORS | TARGEGEN, INC. (US) | 2008-01-31 | — | — | US | disclosed |
| US-20080027070-A1 | 2-AMINO--5-SUBSTITUTED PYRIMIDINE INHIBITORS | TARGEGEN, INC. (US) | 2008-01-31 | — | — | US | disclosed |
| WO-2008008234-A1 | 2-AMINO-5-SUBSTITUTED PYRIMIDINE INHIBITORS | TARGEGEN, INC. (US) | 2008-01-17 | — | — | WO | disclosed |
| WO-2008008234-A1 | 2-AMINO-5-SUBSTITUTED PYRIMIDINE INHIBITORS | TARGEGEN, INC. (US) | 2008-01-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140378516-A1 | COMPOSITIONS, METHODS OF USE, AND METHODS OF TREATMENT | LIPA, LCT, GAA | KCNK3 4371/4885LMNA 343/4885MAPT 2458/4885 |
| US-10604493-B2 | Compositions, methods of use, and methods of treatment | LIPA, LCT, GAA | KCNK3 4371/4885LMNA 343/4885MAPT 2458/4885 |
| US-20170088524-A1 | Compositions, Methods of Use, And Methods of Treatment | LIPA, LCT, GAA | KCNK3 4371/4885LMNA 343/4885MAPT 2458/4885 |
| US-20080027070-A1 | 2-AMINO--5-SUBSTITUTED PYRIMIDINE INHIBITORS | KDR, FLT4, FLT1 | KCNK3 2714/4885LMNA 4793/4885MAPT 3941/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.