Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Valethamate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 10/20 | 1.00 |
| ▸ | CHRM2 known ✓ | P08172 | 9/20 | 1.00 |
| ▸ | CHRM3 known ✓ | P20309 | 8/20 | 1.00 |
| ▸ | CHRM4 known ✓ | P08173 | 6/20 | 1.00 |
| ▸ | CHRM5 known ✓ | P08912 | 1/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 3/20 | 1.00 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 1.00 |
| ▸ | SCN1A | P35498 | 2/20 | 0.47 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.47 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KLK7 | P49862 | 1/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Valethamate SCHEMBL249537 | 0.99 | CHRM1 (0.97) | CHRM1CHRM2CHRM3CHRM4CYP2D6 | |
| Valethamate SCHEMBL10011072 | 0.97 | CHRM1 (0.95) | CHRM1CHRM2CHRM3CHRM4CYP2D6 | |
| SCHEMBL4964029 | 0.75 | KMT2A (0.70) | CHRM1CHRM2CHRM3CHRM4CYP2D6 | |
| Bromide SCHEMBL9325014 | 0.74 | CHRM1 (0.60) | CHRM1CHRM2CHRM3CHRM4CYP2D6 | |
| Bromide SCHEMBL9325007 | 0.73 | CHRM1 (0.57) | CHRM1CHRM2CHRM3CHRM4CYP2D6 | |
| SCHEMBL7878308 | 0.72 | CHRM2 (0.58) | CHRM1CHRM2CHRM3CHRM4CYP2D6 | |
| SCHEMBL7713699 | 0.72 | CHRM1 (0.56) | CHRM1CHRM2CHRM3CHRM4CYP2D6 | |
| SCHEMBL13532000 | 0.72 | CHRM1 (0.60) | CHRM1CHRM2CHRM3CHRM4CYP2D6 | |
| SCHEMBL23872457 | 0.71 | CYP2D6 (0.61) | CHRM1CHRM2CHRM3CHRM4CYP2D6 | |
| SCHEMBL499471 | 0.71 | CYP2D6 (0.61) | CHRM1CHRM2CHRM3CHRM4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 296 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4741009-A2 | MYOGENIC PROGENITOR CELLS FOR USE IN AN OPTIMIZED METHOD FOR THE PREVENTION AND TREATMENT OF ANAL INCONTINENCE | Innovacell GmbH (AT) | 2026-05-13 | — | — | EP | claimed |
| EP-4380583-B1 | MYOGENIC PROGENITOR CELLS FOR USE IN AN OPTIMIZED METHOD FOR THE PREVENTION AND TREATMENT OF ANAL INCONTINENCE | INNOVACELL GMBH (AT) | 2026-04-08 | — | — | EP | claimed |
| US-20250114405-A1 | MYOGENIC PROGENITOR CELLS FOR USE IN AN OPTIMIZED METHOD FOR THE PREVENTION AND TREATMENT OF ANAL INCONTINENCE | INNOVACELL GMBH (AT) | 2025-04-10 | — | — | US | claimed |
| CN-111025345-B | Pseudo-range precision calibration method and system for GNSS signal acquisition playback equipment | 北京无线电计量测试研究所 | 2021-12-14 | — | — | CN | claimed |
| US-10910674-B2 | Additive for increasing lifespan of rechargeable zinc-anode batteries | RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW NEW YORK (US) | 2021-02-02 | — | — | US | claimed |
| CN-111025345-A | Pseudo-range precision calibration method and system for GNSS signal acquisition playback equipment | 北京无线电计量测试研究所 | 2020-04-17 | — | — | CN | claimed |
| US-20180316064-A1 | Additive for Increasing Lifespan of Rechargeable Zinc-Anode Batteries | RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW NEW YORK (US) | 2018-11-01 | — | — | US | claimed |
| WO-2017147104-A1 | MUSCARINIC M2-ANTAGONIST COMBINATIONS | CHASE PHARMACEUTICALS CORPORATION (US) | 2017-08-31 | — | — | WO | claimed |
| CN-106977608-A | Albumin derivant and variant | 阿尔布麦狄克斯公司 | 2017-07-25 | — | — | CN | claimed |
| CN-102939304-A | Albumin derivatives and variants | NOVOZYMES BIOPHARMA UK LTD | 2013-02-20 | — | — | CN | claimed |
| WO-2004032900-A1 | AGGREGATE WITH INCREASED DEFORMABILITY, COMPRISING AT LEAST THREE AMPHIPATS, FOR IMPROVED TRANSPORT THROUGH SEMI-PERMEABLE BARRIERS AND FOR THE NON-INVASIVE DRUG APPLICATION IN VIVO, ESPECIALLY THROUGH THE SKIN | IDEA AG (DE) | 2004-04-22 | — | — | WO | claimed |
| EP-1273301-A2 | Pharmaceutical preparations based on active ingredients susceptible to illicit administration | ALTERGON S.A. (CH) | 2003-01-08 | — | — | EP | claimed |
| CN-1294519-A | Pharmaceutical composition containing a compound having an activity of promoting the absorption of an active ingredient | INPHARMA SA (CH) | 2001-05-09 | — | — | CN | claimed |
| EP-1073470-A1 | PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS | INPHARMA S.A. (CH) | 2001-02-07 | — | — | EP | claimed |
| WO-2000048636-A1 | PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS | INPHARMA S.A. (CH) | 2000-08-24 | — | — | WO | claimed |
| US-5811547-A | Method for inducing crystalline state transition in medicinal substance | NIPPON SHINYAJU CO., LTD. (JP) | 1998-09-22 | — | — | US | claimed |
| US-5008111-A | Pretreating skin with anticholinergic quaternary ammonium salt to suppress perspiration | SCHERING CORPORATION (US) | 1991-04-16 | — | — | US | claimed |
| US-4824676-A | ANTICHOLINERGIC AGENT TO SUPPRESS PERSPIRATION | SCHERING CORPORATION (US) | 1989-04-25 | — | — | US | claimed |
| EP-0189861-A2 | Percutaneous absorption accelerator for ionic water-soluble medicine | SHOWA DENKO KABUSHIKI KAISHA (JP) | 1986-08-06 | — | — | EP | claimed |
| CN-85100892-A | Paper ion exchange membrane and preparation method thereof and application thereof in electrodialysis water purification treatment | — | 1986-01-10 | — | — | CN | claimed |