Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 9/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.38 |
| ▸ | PGR | P06401 | 2/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.38 |
| ▸ | SMO | Q99835 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | SCN2B | O60939 | 1/20 | 0.34 |
| ▸ | SCN1B | Q07699 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | CCNK | O75909 | 1/20 | 0.32 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL445887 | 0.91 | NR3C1 (0.39) | NR3C1CYP11B2PGRCYP11B1SMO | |
| SCHEMBL442111 | 0.88 | PDE10A (0.41) | NR3C1CYP11B2PGRCYP11B1 | |
| SCHEMBL442589 | 0.82 | PDE10A (0.41) | NR3C1CYP11B2PGRCYP11B1 | |
| SCHEMBL442732 | 0.79 | PDE10A (0.41) | NR3C1CYP11B2PGRCYP11B1SMO | |
| SCHEMBL411373 | 0.76 | NR3C1 (0.64) | NR3C1PGR | |
| SCHEMBL411372 | 0.71 | NR3C1 (0.62) | NR3C1PGR | |
| SCHEMBL411954 | 0.66 | NR3C1 (0.50) | NR3C1PGR | |
| SCHEMBL413192 | 0.65 | NR3C1 (0.45) | NR3C1CYP11B2PGRCYP11B1SMO | |
| SCHEMBL6281960 | 0.65 | CYP11B2 (0.59) | NR3C1CYP11B2CYP11B1SMOMAPK1 | |
| SCHEMBL442110 | 0.64 | NR3C1 (0.60) | NR3C1PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8030340-B2 | Moderators of glucocorticoids receptor; antiinflamamtory agents; chronic obstructive pulmonary disease | ASTRAZENECA AB (SE) | 2011-10-04 | — | — | US | claimed |
| US-8030340-B2 | Moderators of glucocorticoids receptor; antiinflamamtory agents; chronic obstructive pulmonary disease | ASTRAZENECA AB (SE) | 2011-10-04 | — | — | US | disclosed |