Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 7/20 | 0.59 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.53 |
| ▸ | SMO | Q99835 | 2/20 | 0.44 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | NPBWR1 | P48145 | 6/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6185201 | 0.88 | CYP11B2 (0.59) | CYP11B2CYP11B1SMONPBWR1MCHR1 | |
| SCHEMBL6282015 | 0.80 | CYP11B1 (0.61) | CYP11B2CYP11B1NPBWR1NPSR1NR3C1 | |
| SCHEMBL6209189 | 0.78 | CYP11B2 (0.53) | CYP11B2CYP11B1SMONR3C1RAB9A | |
| SCHEMBL6183604 | 0.77 | MMP13 (0.48) | CYP11B2 | |
| SCHEMBL6183317 | 0.77 | PGR (0.55) | CYP11B2CYP11B1SMOCYP19A1NPBWR1 | |
| SCHEMBL4456778 | 0.75 | CYP11B2 (0.50) | CYP11B2CYP11B1SMONR3C1 | |
| SCHEMBL6208856 | 0.74 | CYP11B2 (0.49) | CYP11B2SMOSMN1; SMN2NPSR1RAB9A | |
| SCHEMBL15825125 | 0.74 | CYP11B2 (0.69) | CYP11B2CYP11B1SMOCYP19A1NR3C1 | |
| SCHEMBL15839046 | 0.74 | CYP11B2 (1.00) | CYP11B2CYP11B1SMOCYP1A2NR3C1 | |
| SCHEMBL3017074 | 0.74 | CYP11B2 (0.69) | CYP11B2CYP11B1SMOCYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6919332-B2 | N-substituted-heteroaryloxy-aryloxy-pyrimidine-2,4,6-trione metalloproteinase inhibitors | PFIZER INC. (US) | 2005-07-19 | — | — | US | disclosed |
| US-20030232849-A1 | N-substituted-heteroaryloxy-aryloxy-pyrimidine-2,4,6-trione metalloproteinase inhibitors | PFIZER INC. | 2003-12-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030232849-A1 | N-substituted-heteroaryloxy-aryloxy-pyrimidine-2,4,6-trione metalloproteinase inhibitors | MMP8, MMP9, MMP1 | CYP11B2 702/4885CYP11B1 585/4885SMO 2167/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.