SCHEMBL24959709

SCHEMBL24959709

CCC(F)(CC)c1cc(N)on1

nearest known ligand 0.34

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.30
ALDH1A1 P00352 1/20 0.30
MAPT P10636 1/20 0.30
BLM P54132 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9713142 0.78 KDM4E (0.31) KDM4EALDH1A1MAPTBLM
SCHEMBL2676735 0.78 MAPK14 (0.37) KDM4EALDH1A1MAPTBLM
SCHEMBL1012946 0.78 ALDH1A1 (0.33) KDM4EALDH1A1MAPTBLM
SCHEMBL1012674 0.78 BRD4 (0.33) KDM4EALDH1A1MAPTBLM
SCHEMBL573342 0.77 CA2 (0.40) KDM4EALDH1A1MAPTBLM
SCHEMBL1083433 0.74 KDM4E (0.31) KDM4EALDH1A1MAPTBLM
SCHEMBL24410810 0.74 KDM4E (0.31) KDM4EALDH1A1MAPTBLM
SCHEMBL11249883 0.74
SCHEMBL8765031 0.74 KDM4E (0.32) KDM4EALDH1A1MAPTBLM
SCHEMBL1013262 0.73 CNR2 (0.30) KDM4EALDH1A1MAPTBLM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023288253-A1 SMALL MOLECULES INHIBITORS OF CYCLIC GMP-AMP SYNTHASE (CGAS) THE SCRIPPS RESEARCH INSTITUTE (US) 2023-01-19 WO disclosed