Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | KDM5A | P29375 | 1/20 | 0.35 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 4/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | CDC7 | O00311 | 2/20 | 0.31 |
| ▸ | DBF4 | Q9UBU7 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2498957 | 0.85 | MEN1 (0.39) | MEN1KMT2APARP1SMN1; SMN2PDPK1 | |
| SCHEMBL7856465 | 0.78 | JAK2 (0.36) | MEN1KMT2APARP1SMN1; SMN2PDPK1 | |
| SCHEMBL3068246 | 0.78 | TAAR1 (0.41) | PARP1SMN1; SMN2 | |
| SCHEMBL28278903 | 0.78 | DAO (0.40) | PARP1SMN1; SMN2PDPK1CA12ALOX15 | |
| SCHEMBL7856331 | 0.75 | ADORA3 (0.40) | MEN1KMT2A | |
| SCHEMBL7576846 | 0.74 | LOXL2 (0.44) | MEN1KMT2APARP1SMN1; SMN2PDPK1 | |
| SCHEMBL7346990 | 0.74 | PARP1 (0.43) | MEN1KMT2APARP1SMN1; SMN2PDPK1 | |
| SCHEMBL2501354 | 0.74 | PARP1 (0.40) | MEN1KMT2APARP1SMN1; SMN2PDPK1 | |
| SCHEMBL27457721 | 0.74 | PARP1 (0.40) | MEN1KMT2APARP1SMN1; SMN2PDPK1 | |
| SCHEMBL1647059 | 0.74 | PARP1 (0.36) | MEN1KMT2APARP1SMN1; SMN2PDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2373628-A1 | NOVEL COMPOUNDS | Glaxo Group Limited (GB) | 2011-10-12 | — | — | EP | disclosed |
| WO-2010070021-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2010-06-24 | — | — | WO | disclosed |