Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | BRD4 | O60885 | 3/20 | 0.43 |
| ▸ | PLK1 | P53350 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | DRD4 | P21917 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.40 |
| ▸ | IGF1R | P08069 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2205214 | 0.88 | ALDH1A1 (0.50) | ALDH1A1MAPK1KMT2AMEN1BRD4 | |
| SCHEMBL2207626 | 0.87 | ALDH1A1 (0.49) | ALDH1A1MAPK1KMT2AMEN1BRD4 | |
| SCHEMBL13942505 | 0.82 | KMT2A (0.47) | KMT2ABRD4PLK1LMNADRD2 | |
| SCHEMBL2206927 | 0.82 | KMT2A (0.47) | ALDH1A1KMT2ABRD4PLK1KDM4E | |
| SCHEMBL24960728 | 0.80 | CHRM2 (0.49) | ALDH1A1KMT2AMEN1KDM4EPOLB | |
| SCHEMBL2205689 | 0.78 | IGF1R (0.48) | KMT2ABRD4PLK1LMNADRD2 | |
| SCHEMBL2206556 | 0.77 | IGF1R (0.47) | ALDH1A1KMT2AMEN1BRD4PLK1 | |
| SCHEMBL24960657 | 0.77 | REN (0.39) | ALDH1A1MAPK1KMT2AMEN1LMNA | |
| SCHEMBL2206864 | 0.77 | IGF1R (0.49) | ALDH1A1KMT2AMEN1PLK1LMNA | |
| SCHEMBL24960644 | 0.76 | MEN1 (0.50) | ALDH1A1MAPK1KMT2AMEN1BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230026840-A1 | COMPOUND USED AS EGFR KINASE INHIBITOR AND USE THEREOF | TYK MEDICINES, INC. (CN) | 2023-01-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230026840-A1 | COMPOUND USED AS EGFR KINASE INHIBITOR AND USE THEREOF | EGFR, ERBB2, ERBB4 | ALDH1A1 3668/4885MAPK1 54/4885KMT2A 2376/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.