Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14417074 | 0.90 | TP53 (0.50) | SMN1; SMN2ALDH1A1TP53CYP2D6POLB | |
| SCHEMBL3281160 | 0.83 | ALDH1A1 (0.42) | SMN1; SMN2ALDH1A1LTA4HTP53POLB | |
| SCHEMBL25664000 | 0.81 | PIK3CD (0.47) | SMN1; SMN2ALDH1A1CYP2D6POLBKDM4E | |
| SCHEMBL22675502 | 0.81 | SMN1; SMN2 (0.52) | SMN1; SMN2ALDH1A1LTA4HTP53POLB | |
| SCHEMBL25663999 | 0.81 | PIK3CD (0.47) | SMN1; SMN2ALDH1A1CYP2D6POLBKDM4E | |
| SCHEMBL23375191 | 0.81 | SMN1; SMN2 (0.52) | SMN1; SMN2ALDH1A1LTA4HTP53POLB | |
| SCHEMBL12443041 | 0.81 | POLB (0.47) | SMN1; SMN2ALDH1A1POLBKDM4ETDP1 | |
| SCHEMBL16556615 | 0.81 | SMN1; SMN2 (0.52) | SMN1; SMN2ALDH1A1LTA4HTP53POLB | |
| SCHEMBL25664009 | 0.81 | PIK3CD (0.47) | SMN1; SMN2ALDH1A1CYP2D6POLBKDM4E | |
| SCHEMBL24633509 | 0.80 | TP53 (0.47) | SMN1; SMN2ALDH1A1LTA4HTP53POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4234030-A2 | PD-1/PD-L1 INHIBITORS | Gilead Sciences, Inc. (US) | 2023-08-30 | — | — | EP | disclosed |
| WO-2023006019-A1 | POLYSUBSTITUTED BENZENE PD-L1 INHIBITOR, COMPOSITION AND USE THEREOF | 杭州和正医药有限公司 | 2023-02-02 | — | — | WO | disclosed |