Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.45 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.40 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12142079 | 0.83 | NOTUM (0.51) | NOTUMALDH1A1LMNAKDM4EPDE3B | |
| SCHEMBL250868 | 0.83 | ALDH1A1 (0.51) | NOTUMALDH1A1LMNAKDM4EPDE3B | |
| SCHEMBL250808 | 0.81 | NOTUM (0.49) | NOTUMALDH1A1LMNAKDM4EPDE3B | |
| SCHEMBL20716309 | 0.76 | NPC1 (0.52) | NOTUMALDH1A1LMNAKDM4EPDE3B | |
| SCHEMBL24680705 | 0.75 | NOTUM (0.54) | NOTUMALDH1A1LMNAKDM4EPDE3B | |
| SCHEMBL249879 | 0.75 | NOTUM (0.58) | NOTUMALDH1A1LMNAKDM4EPDE3B | |
| SCHEMBL1929073 | 0.75 | MAPT (0.61) | NOTUMALDH1A1LMNAKDM4EPDE3B | |
| SCHEMBL31210319 | 0.75 | MAPT (0.61) | NOTUMALDH1A1LMNAKDM4EPDE3B | |
| SCHEMBL29623590 | 0.75 | NOTUM (0.54) | NOTUMALDH1A1LMNAKDM4EPDE3B | |
| SCHEMBL7911412 | 0.75 | NOTUM (0.54) | NOTUMALDH1A1LMNAKDM4EPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401275-A1 | NOVEL BRONCHODILATING DIAZAHETEROARYLS | Respiratorius AB (SE) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010097410-A1 | NOVEL BRONCHODILATING DIAZAHETEROARYLS | RESPIRATORIUS AB (SE) | 2010-09-02 | — | — | WO | disclosed |