Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.49 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.48 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.48 |
| ▸ | PRKDC | P78527 | 1/20 | 0.47 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.45 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.45 |
| ▸ | PHGDH | O43175 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.44 |
| ▸ | MGLL | Q99685 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17102319 | 0.81 | NOTUM (0.54) | NOTUMLMNAKDM4EALDH1A1PDE3B | |
| SCHEMBL29623590 | 0.81 | NOTUM (0.54) | NOTUMLMNAKDM4EALDH1A1PDE3B | |
| SCHEMBL7911412 | 0.81 | NOTUM (0.54) | NOTUMLMNAKDM4EALDH1A1PDE3B | |
| SCHEMBL24681546 | 0.81 | POLB (0.59) | KDM4EALDH1A1PDE3BPDE3AMAPT | |
| SCHEMBL1929073 | 0.81 | MAPT (0.61) | NOTUMLMNAKDM4EALDH1A1PDE3B | |
| SCHEMBL249879 | 0.81 | NOTUM (0.58) | NOTUMLMNAKDM4EALDH1A1PDE3B | |
| SCHEMBL443520 | 0.81 | HTR3A (0.51) | PHGDHTP53THRBHTT | |
| SCHEMBL31210319 | 0.81 | MAPT (0.61) | NOTUMLMNAKDM4EALDH1A1PDE3B | |
| SCHEMBL17543305 | 0.79 | PHGDH (0.44) | NOTUMPDE3BPDE3AMAPTSMN1; SMN2 | |
| SCHEMBL12139639 | 0.78 | ALDH1A1 (0.56) | NOTUMLMNAKDM4EALDH1A1PDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022226667-A1 | SUBSTITUTED AMINO PYRIDINE COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2022-11-03 | — | — | WO | disclosed |