Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.50 |
| ▸ | SPR | P35270 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.43 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.43 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.43 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.43 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.43 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.43 |
| ▸ | ESRRB | O95718 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2500604 | 1.00 | NLRP3 (0.50) | NLRP3SPREGFRSLC7A5ALDH1A1 | |
| SCHEMBL27810401 | 1.00 | NLRP3 (0.50) | NLRP3SPREGFRSLC7A5ALDH1A1 | |
| SCHEMBL12191879 | 0.86 | L3MBTL1 (0.43) | NLRP3ALDH1A1GRIA2MAPK1 | |
| SCHEMBL2496064 | 0.86 | L3MBTL1 (0.43) | NLRP3ALDH1A1GRIA2MAPK1 | |
| SCHEMBL12191878 | 0.86 | L3MBTL1 (0.43) | NLRP3ALDH1A1GRIA2MAPK1 | |
| SCHEMBL6384666 | 0.85 | NLRP3 (0.51) | NLRP3SPREGFRGRIA2GABRA1 | |
| SCHEMBL8802162 | 0.84 | ALDH1A1 (0.47) | SLC7A5ALDH1A1THRBCYP2C9CYP2C19 | |
| SCHEMBL6028187 | 0.84 | TAAR1 (0.54) | SLC7A5MEN1KMT2A | |
| SCHEMBL27705535 | 0.84 | NLRP3 (0.50) | NLRP3SPREGFRGRIA2GABRA1 | |
| SCHEMBL13085683 | 0.84 | NLRP3 (0.50) | NLRP3SPREGFRGRIA2GABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8030354-B2 | 2-(5,5-Dimethylcyclopent-1-enyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; metabolic disorders such as type II diabetes | AMGEN INC. (US) | 2011-10-04 | — | — | US | disclosed |
| CN-102083783-A | Substituted biphenyl GPR40 modulators | AMGEN INC | 2011-06-01 | — | — | CN | disclosed |