Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.54 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.54 |
| ▸ | CTSA | P10619 | 1/20 | 0.53 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.51 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | DHODH | Q02127 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.47 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.47 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2496100 | 0.87 | CTSA (0.50) | ALDH1A1MAPK1CTSACHEK2TP53 | |
| SCHEMBL12190965 | 0.82 | RAB9A (0.64) | ALDH1A1CTSATP53KDM4EPKM | |
| SCHEMBL2945422 | 0.81 | ALDH1A1 (0.73) | ALDH1A1MAPK1SRD5A2CHEK2GABRA1 | |
| SCHEMBL2501789 | 0.80 | CTSA (0.48) | ALDH1A1MAPK1CTSACHEK2TP53 | |
| SCHEMBL12190962 | 0.79 | FYN (0.56) | ALDH1A1MAPK1CTSACHEK2TP53 | |
| SCHEMBL12190973 | 0.78 | NPC1 (0.68) | CTSAKDM4EPKMHPGDKMT2A | |
| SCHEMBL12190957 | 0.78 | CTSA (0.65) | ALDH1A1MAPK1CTSAKDM4EGABRA1 | |
| SCHEMBL12190958 | 0.78 | CTSA (0.65) | ALDH1A1MAPK1CTSAKDM4EGABRA1 | |
| SCHEMBL3181717 | 0.77 | MKNK1 (0.69) | ALDH1A1MKNK1MKNK2KDM4EKMT2A | |
| SCHEMBL12190981 | 0.76 | CTSA (0.63) | ALDH1A1CTSATP53KDM4EPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1569907-B1 | NICOTINAMIDE-BASED KINASE INHIBITORS | YM BIOSCIENCES AUSTRALIA PTY (AU) | 2016-03-09 | — | — | EP | disclosed |
| US-8030336-B2 | Nicotinamide-based kinase inhibitors | YM BIOSCIENCES AUSTRALIA PTY LTD (AU) | 2011-10-04 | — | — | US | disclosed |
| EP-1569907-A4 | NICOTINAMIDE-BASED KINASE INHIBITORS | CYTOPIA PTY LTD (AU) | 2007-10-31 | — | — | EP | disclosed |
| US-20070060619-A1 | Nicotinamide-based kinase inhibitors | CYTOPIA PTY LTD (AU) | 2007-03-15 | — | — | US | disclosed |
| EP-1569907-A1 | NICOTINAMIDE-BASED KINASE INHIBITORS | Cytopia PTY Ltd (AU) | 2005-09-07 | — | — | EP | disclosed |
| WO-2004054977-A1 | NICOTINAMIDE-BASED KINASE INHIBITORS | CYTOPIA PTY LTD (AU) | 2004-07-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070060619-A1 | Nicotinamide-based kinase inhibitors | NADK, NAMPT, PDXK | ALDH1A1 1092/4885MAPK1 48/4885MKNK1 228/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.