Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 2/20 | 0.68 |
| ▸ | MAOB | P27338 | 2/20 | 0.68 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.50 |
| ▸ | DRD1 | P21728 | 4/20 | 0.48 |
| ▸ | DRD5 | P21918 | 3/20 | 0.48 |
| ▸ | DRD3 | P35462 | 2/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | DRD4 | P21917 | 1/20 | 0.48 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL130712 | 0.97 | MAOA (0.71) | MAOAMAOBSLC6A3SLC6A2SLC6A4 | |
| Bromide SCHEMBL2646357 | 0.94 | MAOA (0.68) | MAOAMAOBSLC6A3SLC6A2SLC6A4 | |
| SCHEMBL24227957 | 0.89 | DRD1 (0.62) | MAOAMAOBSLC6A3SLC6A2SLC6A4 | |
| SCHEMBL1649346 | 0.83 | MAOA (0.56) | MAOAMAOBSLC6A3SLC6A2SLC6A4 | |
| SCHEMBL98108 | 0.81 | MAOA (1.00) | MAOAMAOBSLC6A3SLC6A2SLC6A4 | |
| SCHEMBL29390912 | 0.81 | MAOA (1.00) | MAOAMAOBSLC6A3SLC6A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL23501375 | 0.79 | MAOA (1.00) | MAOAMAOBSLC6A3SLC6A2SLC6A4 | |
| SCHEMBL14573056 | 0.79 | MAOA (0.56) | MAOAMAOBSLC6A3DRD1DRD5 | |
| SCHEMBL14306400 | 0.78 | HSD17B3 (0.49) | MAOAMAOBSLC6A3SLC6A2SLC6A4 | |
| SCHEMBL4320673 | 0.78 | MAOA (0.91) | MAOAMAOBSLC6A3SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230026616-A1 | PYRIMIDOIMIDAZOLE COMPOUNDS USED AS DNA-PK INHIBITORS | ZAI LAB (SHANGHAI) CO., LTD (CN) | 2023-01-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230026616-A1 | PYRIMIDOIMIDAZOLE COMPOUNDS USED AS DNA-PK INHIBITORS | TYMP, DTYMK, DCK | MAOA 4007/4885MAOB 3191/4885SLC6A3 1624/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.