Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | MEN1 | O00255 | 5/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.39 |
| ▸ | USP2 | O75604 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | CASP1 | P29466 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2406232 | 0.85 | LMNA (0.47) | GBA1LMNAALDH1A1MEN1KMT2A | |
| SCHEMBL2401717 | 0.80 | KMT2A (0.45) | GBA1LMNAALDH1A1MEN1KMT2A | |
| SCHEMBL2401402 | 0.78 | HTR3E (0.50) | GBA1LMNAALDH1A1MEN1KMT2A | |
| SCHEMBL2402671 | 0.77 | HRH4 (0.50) | GBA1LMNAALDH1A1MEN1KMT2A | |
| SCHEMBL2401877 | 0.76 | HRH4 (0.47) | GBA1LMNAALDH1A1MEN1KMT2A | |
| SCHEMBL2400823 | 0.76 | ALDH1A1 (0.46) | GBA1LMNAALDH1A1MEN1KMT2A | |
| SCHEMBL2401793 | 0.75 | ALDH1A1 (0.48) | GBA1LMNAALDH1A1MEN1KMT2A | |
| SCHEMBL2405703 | 0.74 | SRC (0.53) | GBA1LMNAALDH1A1MEN1KMT2A | |
| SCHEMBL2403895 | 0.73 | FLT3 (0.43) | LMNAALDH1A1MEN1KMT2APDE10A | |
| SCHEMBL2401462 | 0.71 | CDK4 (0.47) | GBA1ALDH1A1MEN1KMT2APDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2545058-A2 | HETEROCYCLIC INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE | Kalypsys, Inc. (US) | 2013-01-16 | — | — | EP | disclosed |
| WO-2011112766-A2 | HETEROCYCLIC INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2011-09-15 | — | — | WO | disclosed |