SCHEMBL2496761

SCHEMBL2496761

C=CC(=O)OC(CC)[SiH2]OC(C(C)C)C(C)C

nearest known ligand 0.37

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.37
HPGD P15428 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28467863 0.87 TSHR (0.39) TSHRHPGD
SCHEMBL1019122 0.80 TSHR (0.37) TSHRHPGD
SCHEMBL5958279 0.78 TSHR (0.36) TSHRHPGD
SCHEMBL1015222 0.78 TSHR (0.36) TSHRHPGD
SCHEMBL2491513 0.77 TSHR (0.37) TSHR
SCHEMBL29022841 0.77 TSHR (0.39) TSHRHPGD
SCHEMBL1015617 0.75 TSHR (0.39) TSHRHPGD
SCHEMBL8853600 0.75 TSHR (0.39) TSHRHPGD
SCHEMBL28476202 0.75 TSHR (0.41) TSHRHPGD
SCHEMBL9056583 0.75 TSHR (0.34) TSHRHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7279527-B2 Method of converting anionic living end to protected free radical living end and applications thereof BRIDGESTONE CORPORATION (JP) 2007-10-09 US claimed
US-20060241265-A1 Method of converting anionic living end to protected free radical living end and applications thereof BRIDGESTONE CORPORATION (JP) 2006-10-26 US claimed
US-6376615-B1 USING FREE RADICALS CENTRO DE INVESTIGACION EN QUIMICA APLICADA (MX) 2002-04-23 US claimed
US-8030410-B2 Reacting anionic living end polymer that is end capped with steric hindering carbonyl-containing compound to produce polymer with homolytically cleaveable group; engineering plastics BRIDGESTONE CORPORATION (JP) 2011-10-04 US disclosed
US-7737218-B2 Method for generating free radical capable polymers using tin or silicon halide compounds BRIDGESTONE CORPORATION (JP) 2010-06-15 US disclosed
US-7560509-B2 Method of directing grafting by controlling the location of high vinyl segments in a polymer BRIDGESTONE CORPORATION (JP) 2009-07-14 US disclosed
US-20080161495-A1 Method for Generating Free Radical Capable Polymers Using Tin or Silicon Halide Compounds BRIDGESTONE CORPORATION (JP) 2008-07-03 US disclosed
US-20080161484-A1 Method of Directing Grafting by Controlling the Location of High Vinyl Segments in a Polymer BRIDGESTONE CORPORATION (JP) 2008-07-03 US disclosed
US-20080161501-A1 Method for generating free radical capable polymers using carbonyl-containing compounds BRIDGESTONE CORPORATION (JP) 2008-07-03 US disclosed
US-7279527-B2 Method of converting anionic living end to protected free radical living end and applications thereof BRIDGESTONE CORPORATION (JP) 2007-10-09 US disclosed
US-20060241265-A1 Method of converting anionic living end to protected free radical living end and applications thereof BRIDGESTONE CORPORATION (JP) 2006-10-26 US disclosed
US-6376615-B1 USING FREE RADICALS CENTRO DE INVESTIGACION EN QUIMICA APLICADA (MX) 2002-04-23 US disclosed