⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochlorthiazide SCHEMBL353307 | 0.91 | FFAR3 (0.30) | — | |
| Hydrochlorthiazide SCHEMBL352730 | 0.90 | — | — | |
| Hydrochlorthiazide SCHEMBL15656554 | 0.90 | — | — | |
| Hydrochlorthiazide SCHEMBL27521699 | 0.88 | FFAR3 (0.32) | — | |
| Hydrochlorthiazide SCHEMBL2581931 | 0.88 | — | — | |
| Hydrochlorthiazide SCHEMBL10585431 | 0.88 | ALDH1A1 (0.32) | — | |
| Hydrochlorthiazide SCHEMBL4940467 | 0.88 | ALDH1A1 (0.32) | — | |
| Hydrochlorthiazide SCHEMBL677154 | 0.88 | — | — | |
| Hydrochlorthiazide SCHEMBL29120814 | 0.86 | — | — | |
| Hydrochlorthiazide SCHEMBL29079282 | 0.86 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103380115-A | Sulfur derivatives as chemokine receptor modulators | ALLERGAN INC | 2013-10-30 | — | — | CN | claimed |
| EP-1458382-A1 | AMIDE DERIVATIVES AS GK ACTIVATORS | NOVO NORDISK A/S (DK) | 2004-09-22 | — | — | EP | claimed |
| WO-2003055482-A1 | AMIDE DERIVATIVES AS GK ACTIVATORS | NOVO NORDISK A/S (DK) | 2003-07-10 | — | — | WO | claimed |
| CN-105748470-A | Application of thiazole acetamide compound to reduction of serum total cholesterol of obese patients | 王彩兰 | 2016-07-13 | — | — | CN | disclosed |
| CN-105748470-A | Application of thiazole acetamide compound to reduction of serum total cholesterol of obese patients | 王彩兰 | 2016-07-13 | — | — | CN | disclosed |
| CN-105748470-A | Application of thiazole acetamide compound to reduction of serum total cholesterol of obese patients | 王彩兰 | 2016-07-13 | — | — | CN | disclosed |
| CN-105612162-A | Thiazolopyrimidinones as modulators of NMDA receptor activity | HOFFMANN LA ROCHE | 2016-05-25 | — | — | CN | disclosed |
| CN-103380115-A | Sulfur derivatives as chemokine receptor modulators | ALLERGAN INC | 2013-10-30 | — | — | CN | disclosed |
| CN-101516887-B | Thiazole pyrazolopyrimidines as crf1 receptor antagonists | LILLY CO ELI | 2011-11-02 | — | — | CN | disclosed |
| US-8030304-B2 | Thiazole pyrazolopyrimidines CRF1 receptor antagonists | ELI LILLY AND COMPANY (US) | 2011-10-04 | — | — | US | disclosed |
| EP-2094709-B1 | THIAZOLE PYRAZOLOPYRIMIDINES AS CRF1 RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2010-09-15 | — | — | EP | disclosed |
| US-20100222339-A1 | Thiazole pyrazolopyrimidines CRF1 receptor antagonists | ELI LILLY AND COMPANY | 2010-09-02 | — | — | US | disclosed |
| EP-2094709-A1 | THIAZOLE PYRAZOLOPYRIMIDINES AS CRF1 RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2009-09-02 | — | — | EP | disclosed |
| CN-101516887-A | Thiazole pyrazolopyrimidines as CRF1 receptor antagonists | LILLY CO ELI (US) | 2009-08-26 | — | — | CN | disclosed |
| WO-2008036579-A1 | THIAZOLE PYRAZOLOPYRIMIDINES AS CRF1 RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2008-03-27 | — | — | WO | disclosed |
| EP-1587800-A1 | THIAZOLE DERIVATIVES AND THEIR USE AS VAP-1 INHIBITORS | Astellas Pharma Inc. (JP) | 2005-10-26 | — | — | EP | disclosed |
| EP-1458382-A1 | AMIDE DERIVATIVES AS GK ACTIVATORS | NOVO NORDISK A/S (DK) | 2004-09-22 | — | — | EP | disclosed |
| WO-2004067521-A1 | THIAZOLE DERIVATIVES AND THEIR USE AS VAP-1 INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2004-08-12 | — | — | WO | disclosed |
| WO-2003055482-A1 | AMIDE DERIVATIVES AS GK ACTIVATORS | NOVO NORDISK A/S (DK) | 2003-07-10 | — | — | WO | disclosed |