Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | BRAF | P15056 | 2/20 | 0.49 |
| ▸ | NAMPT | P43490 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.48 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.48 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.48 |
| ▸ | CSF1R | P07333 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5135347 | 0.90 | KMT2A (0.50) | HPGDPKMBRAFALDH1A1HTT | |
| SCHEMBL27916737 | 0.85 | TAAR1 (0.61) | NPC1RAB9APKMBRAFNAMPT | |
| SCHEMBL9547528 | 0.82 | KMT2A (0.61) | HPGDPKMALDH1A1GAASMN1; SMN2 | |
| SCHEMBL3429605 | 0.81 | NPC1 (0.56) | HPGDNPC1RAB9APKMNAMPT | |
| SCHEMBL27710911 | 0.78 | NPC1 (0.59) | NPC1RAB9APKMNAMPTALDH1A1 | |
| SCHEMBL28251299 | 0.78 | HPGD (0.51) | HPGDPKMALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL27967057 | 0.77 | TAAR1 (0.61) | HPGDNPC1RAB9APKMBRAF | |
| SCHEMBL27967054 | 0.77 | TAAR1 (0.54) | HPGDNPC1RAB9APKMBRAF | |
| SCHEMBL9192069 | 0.76 | KMT2A (0.72) | NPC1RAB9APKMBRAFALDH1A1 | |
| SCHEMBL16557564 | 0.76 | RAB9A (0.71) | HPGDNPC1RAB9AALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2373662-A2 | THIENO[3,2-C]PYRIDINE DERIVATIVES AS KINASE INHIBITORS FOR USE IN THE TREATMENT OF CANCER | Abbott Laboratories (US) | 2011-10-12 | — | — | EP | disclosed |
| WO-2010065825-A2 | KINASE INHIBITORS WITH IMPROVED CYP SAFETY PROFILE | ABBOTT LABORATORIES (US) | 2010-06-10 | — | — | WO | disclosed |