Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.37 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MMP1 | P03956 | 3/20 | 0.36 |
| ▸ | MMP7 | P09237 | 3/20 | 0.36 |
| ▸ | MMP12 | P39900 | 3/20 | 0.36 |
| ▸ | MMP13 | P45452 | 3/20 | 0.36 |
| ▸ | ACE | P12821 | 2/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | WDR5 | P61964 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3415944 | 0.87 | ATM (0.43) | ATMHSD17B2L3MBTL1CA1CA2 | |
| SCHEMBL17396995 | 0.84 | ATM (0.40) | ATMHSD17B2L3MBTL1CA1CA2 | |
| SCHEMBL3917298 | 0.80 | SMN1; SMN2 (0.50) | ATMSMN1; SMN2MMP1MMP7MMP12 | |
| SCHEMBL3629915 | 0.76 | ATM (0.41) | ATMHSD17B2EGFRERBB2KAT6A | |
| SCHEMBL3505980 | 0.75 | ATM (0.41) | ATMHSD17B2EGFRERBB2KAT6A | |
| SCHEMBL1271030 | 0.74 | HSD17B2 (0.42) | ATMHSD17B2CA1CA2CA9 | |
| SCHEMBL1710642 | 0.74 | SMN1; SMN2 (0.49) | ATMHSD17B2L3MBTL1CA2CA9 | |
| SCHEMBL28813913 | 0.73 | MMP1 (0.38) | ATMHSD17B2L3MBTL1MMP1MMP7 | |
| SCHEMBL99072 | 0.72 | PSIP1 (0.56) | ATMHSD17B2EGFRERBB2KAT6A | |
| SCHEMBL263686 | 0.71 | ATM (0.46) | ATMHSD17B2L3MBTL1KAT6AEDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2367801-A1 | POLAR QUINAZOLINES AS LIVER X RECEPTORS ( LXRS ) MODULATORS | Wyeth LLC (US) | 2011-09-28 | — | — | EP | disclosed |
| WO-2010059627-A1 | POLAR QUINAZOLINES AS LIVER X RECEPTORS ( LXRS ) MODULATORS | WYETH LLC (US) | 2010-05-27 | — | — | WO | disclosed |