Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
| ▸ | SLC37A4 | O43826 | 1/20 | 0.36 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.35 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.35 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.35 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | CTSA | P10619 | 1/20 | 0.33 |
| ▸ | BID | P55957 | 3/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.33 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.33 |
| ▸ | BAK1 | Q16611 | 2/20 | 0.33 |
| ▸ | KAT8 | Q9H7Z6 | 2/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2497872 | 1.00 | ADRB1 (0.43) | ADRB1ADRA2AADRB3ADRA2BADRA2C | |
| SCHEMBL3651803 | 0.88 | ADRB1 (0.45) | ADRB1ADRA2AADRB3ADRA2BADRA2C | |
| SCHEMBL2499881 | 0.88 | ADRB1 (0.45) | ADRB1ADRA2AADRB3ADRA2BADRA2C | |
| SCHEMBL3658574 | 0.88 | ADRB1 (0.45) | ADRB1ADRA2AADRB3ADRA2BADRA2C | |
| SCHEMBL13882299 | 0.85 | ADRB1 (0.43) | ADRB1ADRA2AADRB3ADRA2BADRA2C | |
| SCHEMBL2497367 | 0.77 | ADRB1 (0.38) | ADRB1ADRA2AADRB3ADRA2BADRA2C | |
| SCHEMBL11287832 | 0.75 | CTSA (0.43) | GABBR2GABBR1CYSLTR2CYSLTR1CTSA | |
| SCHEMBL9807303 | 0.75 | HPGD (0.54) | — | |
| SCHEMBL2498695 | 0.73 | ADRA2A (0.43) | ADRA2AADRA2BADRA2CCYSLTR2CYSLTR1 | |
| SCHEMBL13871772 | 0.73 | CES2 (0.41) | CTSA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8030354-B2 | 2-(5,5-Dimethylcyclopent-1-enyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; metabolic disorders such as type II diabetes | AMGEN INC. (US) | 2011-10-04 | — | — | US | disclosed |