Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 2/20 | 0.36 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 3/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24976620 | 0.86 | KIT (0.39) | PRMT5WDR77ALDH1A1KDM4EGAA | |
| SCHEMBL19677383 | 0.84 | FLT3 (0.52) | FLT3MAP4K4CYP1A2KDR | |
| SCHEMBL24975909 | 0.83 | FGFR1 (0.35) | ALDH1A1KDM4EGAAPKMFLT3 | |
| SCHEMBL21863416 | 0.81 | FLT3 (0.48) | PRMT5WDR77ALDH1A1KDM4EPKM | |
| SCHEMBL20721438 | 0.80 | FLT3 (0.38) | PRMT5WDR77ALDH1A1KDM4EGAA | |
| SCHEMBL17437915 | 0.79 | ALDH1A1 (0.43) | ALDH1A1KDM4EGAAPKMFGFR1 | |
| SCHEMBL24976174 | 0.77 | PRMT5 (0.39) | PRMT5WDR77ALDH1A1KDM4EGAA | |
| SCHEMBL21593360 | 0.76 | PRMT5 (0.40) | PRMT5WDR77ALDH1A1KDM4EGAA | |
| SCHEMBL24976624 | 0.75 | NEK2 (0.39) | PRMT5WDR77ALDH1A1KDM4EGAA | |
| SCHEMBL23107182 | 0.75 | KIT (0.45) | PRMT5WDR77ALDH1A1KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023009833-A9 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2023-11-23 | — | — | WO | disclosed |
| WO-2023009833-A1 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2023-02-02 | — | — | WO | disclosed |