Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 2/20 | 0.39 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.39 |
| ▸ | FLT3 | P36888 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | PDE8A | O60658 | 4/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | MGLL | Q99685 | 1/20 | 0.32 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.32 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.32 |
| ▸ | ALB | P02768 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | CSF1R | P07333 | 1/20 | 0.31 |
| ▸ | PDE2A | O00408 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21593360 | 0.84 | PRMT5 (0.40) | PRMT5WDR77FLT3KDM4EHPGD | |
| SCHEMBL24976173 | 0.82 | PDE8A (0.32) | FLT3PDE8AMGLLABHD6PDE2A | |
| SCHEMBL24976620 | 0.82 | KIT (0.39) | PRMT5WDR77FLT3KDM4EHPGD | |
| SCHEMBL23889154 | 0.80 | NPC1 (0.38) | KDM4EHPGDALDH1A1GAAGLA | |
| SCHEMBL17437845 | 0.79 | KDM4E (0.47) | KDM4EHPGDALDH1A1GAAGLA | |
| SCHEMBL17438012 | 0.78 | CSF1R (0.36) | KDM4EHPGDALDH1A1GAAGLA | |
| SCHEMBL21863416 | 0.78 | FLT3 (0.48) | PRMT5WDR77FLT3KDM4EHPGD | |
| SCHEMBL20646977 | 0.78 | NPC1 (0.37) | KDM4EHPGDALDH1A1GAAGLA | |
| SCHEMBL23107182 | 0.78 | KIT (0.45) | PRMT5WDR77FLT3KDM4EHPGD | |
| SCHEMBL24976169 | 0.77 | PRMT5 (0.36) | PRMT5WDR77FLT3KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023009833-A9 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2023-11-23 | — | — | WO | disclosed |
| WO-2023009833-A1 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2023-02-02 | — | — | WO | disclosed |