SCHEMBL2498463

SCHEMBL2498463

Nc1nccc(-c2cccs2)c1[N+](=O)[O-]

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 5/20 0.42
ALDH1A1 P00352 4/20 0.42
MAPT P10636 4/20 0.40
HTT P42858 3/20 0.40
MITF O75030 1/20 0.40
NPC1 O15118 1/20 0.39
RAB9A P51151 1/20 0.39
ATM Q13315 1/20 0.39
TDO2 P48775 1/20 0.39
NOD2 Q9HC29 1/20 0.37
GAA P10253 3/20 0.37
HPGD P15428 3/20 0.37
SMN1; SMN2 Q16637 2/20 0.37
GLA P06280 2/20 0.37
HCRTR1 O43613 1/20 0.37
LMNA P02545 2/20 0.37
PIM1 P11309 1/20 0.37
ADORA2A P29274 1/20 0.37
ADORA1 P30542 1/20 0.37
MGMT P16455 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11903738 0.91 DPP4 (0.38) KDM4EALDH1A1MAPTHTTMITF
SCHEMBL11903953 0.91 DPP4 (0.38) KDM4EALDH1A1MAPTHTTMITF
Ethyl Acetate SCHEMBL27690065 0.85 ALDH1A1 (0.45) KDM4EALDH1A1MAPTHTTRAB9A
SCHEMBL2495572 0.76 KDM4E (0.50) KDM4EALDH1A1MAPTNPC1RAB9A
SCHEMBL18454300 0.75 LMNA (0.37) KDM4EALDH1A1MAPTHTTMITF
SCHEMBL17555766 0.75 MAPT (0.37) KDM4EALDH1A1MAPTHTTMITF
SCHEMBL1840937 0.75 MEN1 (0.48) KDM4EALDH1A1MAPTHTTMITF
SCHEMBL17555611 0.75 MAPT (0.44) KDM4EMAPTHTTMITFNOD2
SCHEMBL17555750 0.73 HTT (0.48) KDM4EMAPTHTTMITFNPC1
SCHEMBL27350637 0.72 MAPT (0.35) KDM4EALDH1A1MAPTHTTMITF

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240116924-A1 METHOD FOR PRODUCING IMIDAZOPYRIDINE DERIVATIVE TAGCYX BIOTECHNOLOGIES INC. (JP) 2024-04-11 US disclosed
EP-4286395-A1 METHOD FOR PRODUCING IMIDAZOPYRIDINE DERIVATIVE TAGCyx Biotechnologies Inc. (JP) 2023-12-06 EP disclosed
CN-116745308-A Process for producing imidazopyridine derivative 塔古西库斯生物株式会社 2023-09-12 CN disclosed
WO-2022163764-A1 METHOD FOR PRODUCING IMIDAZOPYRIDINE DERIVATIVE タグシクス・バイオ株式会社 2022-08-04 WO disclosed
EP-1847546-B1 IMIDAZOPYRIDINE DERIVATIVE RIKEN (JP) 2012-11-28 EP disclosed
EP-1847546-B1 IMIDAZOPYRIDINE DERIVATIVE RIKEN (JP) 2012-11-28 EP disclosed
EP-1970445-B1 METHOD FOR NUCLEIC ACID REPLICATION AND NOVEL ARTIFICIAL BASE PAIRS RIKEN (JP) 2012-09-26 EP disclosed
CN-101365791-B Method for replication of nucleic acid and novel artificial base pair RIKEN 2012-07-25 CN disclosed
US-8030478-B2 Method for nucleic acid replication and novel artificial base pairs RIKEN (JP) 2011-10-04 US disclosed
CN-101107261-B Imidazopyridine derivatives RIKEN 2011-02-09 CN disclosed
US-7615628-B2 Imidazopyridine derivatives RIKEN (JP) 2009-11-10 US disclosed
US-7615628-B2 Imidazopyridine derivatives RIKEN (JP) 2009-11-10 US disclosed
CN-101365791-A Method for replication of nucleic acid and novel artificial base pair RIKEN (JP) 2009-02-11 CN disclosed
EP-1970445-A1 METHOD FOR NUCLEIC ACID REPLICATION AND NOVEL ARTIFICIAL BASE PAIRS Riken (JP) 2008-09-17 EP disclosed
US-20080125381-A1 Imidazopyridine Derivatives RIKEN (JP) 2008-05-29 US disclosed
US-20080125381-A1 Imidazopyridine Derivatives RIKEN (JP) 2008-05-29 US disclosed
US-20080125381-A1 Imidazopyridine Derivatives RIKEN (JP) 2008-05-29 US disclosed
CN-101107261-A imidazopyridine derivatives RIKEN (JP) 2008-01-16 CN disclosed
EP-1847546-A1 IMIDAZOPYRIDINE DERIVATIVE Riken (JP) 2007-10-24 EP disclosed
EP-1847546-A1 IMIDAZOPYRIDINE DERIVATIVE Riken (JP) 2007-10-24 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240116924-A1 METHOD FOR PRODUCING IMIDAZOPYRIDINE DERIVATIVE XDH, TH, ABL1 KDM4E 381/4885ALDH1A1 1167/4885MAPT 3161/4885
US-20080125381-A1 Imidazopyridine Derivatives MKI67, IPO5, IMPA1 KDM4E 552/4885ALDH1A1 591/4885MAPT 4483/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.