SCHEMBL24991948

SCHEMBL24991948

CN(C)c1ccc(/C=C2\SC(=S)NC2=S)cc1

nearest known ligand 0.73

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CRHBP P24387 3/20 0.73
CRHR2 Q13324 3/20 0.73
PIM1 P11309 1/20 0.58
PIM2 Q9P1W9 1/20 0.58
MEN1 O00255 1/20 0.48
POLB P06746 1/20 0.48
KMT2A Q03164 1/20 0.48
GPR35 Q9HC97 1/20 0.48
TDP1 Q9NUW8 3/20 0.46
PNP P00491 1/20 0.46
MYC P01106 3/20 0.46
MAX P61244 3/20 0.46
NPC1 O15118 1/20 0.46
RAB9A P51151 1/20 0.46
CSNK2A2 P19784 1/20 0.46
CLK1 P49759 1/20 0.46
CSNK2B P67870 1/20 0.46
CSNK2A1 P68400 1/20 0.46
DYRK1A Q13627 1/20 0.46
DYRK1B Q9Y463 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8186777 0.86 PIM1 (0.74) CRHBPCRHR2PIM1PIM2MEN1
SCHEMBL8186778 0.86 PIM1 (0.74) CRHBPCRHR2PIM1PIM2MEN1
SCHEMBL1249935 0.84 CRHBP (1.00) CRHBPCRHR2PIM1PIM2MEN1
SCHEMBL194557 0.84 CRHBP (1.00) CRHBPCRHR2PIM1PIM2MEN1
SCHEMBL194558 0.84 CRHBP (1.00) CRHBPCRHR2PIM1PIM2MEN1
SCHEMBL8178995 0.83 CRHBP (0.56) CRHBPCRHR2PIM1PIM2MEN1
SCHEMBL8172749 0.77 MYC (0.73) CRHBPCRHR2PIM1PIM2MEN1
SCHEMBL8178027 0.77 CSNK2A2 (0.73) PIM1PIM2MEN1POLBKMT2A
SCHEMBL8178029 0.77 CSNK2A2 (0.73) PIM1PIM2MEN1POLBKMT2A
SCHEMBL8172752 0.77 MYC (0.73) CRHBPCRHR2PIM1PIM2MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023011658-A1 METHOD FOR DETECTING AND QUANTIFYING RNA 纳莹(上海)生物科技有限公司 2023-02-09 WO disclosed
WO-2023011657-A1 METHOD FOR DETECTING AND QUANTIFYING RNA 纳莹(上海)生物科技有限公司 2023-02-09 WO disclosed