Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHBP | P24387 | 1/20 | 0.56 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.56 |
| ▸ | METAP1 | P53582 | 2/20 | 0.55 |
| ▸ | APP | P05067 | 7/20 | 0.50 |
| ▸ | MAPT | P10636 | 7/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | THRB | P10828 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RECQL | P46063 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.49 |
| ▸ | PSMD14 | O00487 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | ALPG | P10696 | 1/20 | 0.49 |
| ▸ | SNCA | P37840 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15347480 | 0.86 | CRHBP (0.72) | CRHBPCRHR2METAP1APPMAPT | |
| SCHEMBL15347679 | 0.86 | CRHBP (0.72) | CRHBPCRHR2METAP1APPMAPT | |
| SCHEMBL12892048 | 0.86 | CRHBP (0.72) | CRHBPCRHR2METAP1APPMAPT | |
| SCHEMBL24991948 | 0.83 | CRHBP (0.73) | CRHBPCRHR2MEN1KMT2ANPC1 | |
| SCHEMBL1249305 | 0.75 | PIM1 (0.72) | CRHBPCRHR2METAP1APPMAPT | |
| SCHEMBL12892017 | 0.75 | PIM1 (0.72) | CRHBPCRHR2METAP1APPMAPT | |
| SCHEMBL8171975 | 0.72 | GSK3B (0.60) | APPMEN1KMT2ATDP1PIM1 | |
| SCHEMBL194558 | 0.72 | CRHBP (1.00) | CRHBPCRHR2MEN1KMT2ANPC1 | |
| SCHEMBL194557 | 0.72 | CRHBP (1.00) | CRHBPCRHR2MEN1KMT2ANPC1 | |
| SCHEMBL1249935 | 0.72 | CRHBP (1.00) | CRHBPCRHR2MEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000018748-A1 | RHODANINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF METABOLIC BONE DISORDERS | ROCHE DIAGNOSTICS GMBH (DE) | 2000-04-06 | — | — | WO | disclosed |