SCHEMBL194558

SCHEMBL194558

CN(C)c1ccc(C=C2SC(=S)NC2=O)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CRHBP P24387 3/20 1.00
CRHR2 Q13324 3/20 1.00
PIM1 P11309 1/20 0.77
PIM2 Q9P1W9 1/20 0.77
NAT1 P18440 5/20 0.66
MYC P01106 3/20 0.66
MAX P61244 3/20 0.66
CISD1 Q9NZ45 1/20 0.66
MEN1 O00255 1/20 0.65
POLB P06746 1/20 0.65
KMT2A Q03164 1/20 0.65
GPR35 Q9HC97 1/20 0.65
NPC1 O15118 1/20 0.65
RAB9A P51151 1/20 0.65
CSNK2A2 P19784 1/20 0.65
CLK1 P49759 1/20 0.65
CSNK2B P67870 1/20 0.65
CSNK2A1 P68400 1/20 0.65
DYRK1A Q13627 1/20 0.65
DYRK1B Q9Y463 1/20 0.65

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL194557 1.00 CRHBP (1.00) CRHBPCRHR2PIM1PIM2NAT1
SCHEMBL1249935 1.00 CRHBP (1.00) CRHBPCRHR2PIM1PIM2NAT1
SCHEMBL14891689 0.91 CRHBP (0.90) CRHBPCRHR2PIM1PIM2NAT1
SCHEMBL14891688 0.91 CRHBP (0.90) CRHBPCRHR2PIM1PIM2NAT1
SCHEMBL1248777 0.87 PIM1 (1.00) CRHBPCRHR2PIM1PIM2CISD1
SCHEMBL2544392 0.87 PIM1 (1.00) CRHBPCRHR2PIM1PIM2CISD1
SCHEMBL1248775 0.87 PIM1 (1.00) CRHBPCRHR2PIM1PIM2CISD1
SCHEMBL24991948 0.84 CRHBP (0.73) CRHBPCRHR2PIM1PIM2NAT1
SCHEMBL1249353 0.84 CRHBP (1.00) CRHBPCRHR2NAT1MYCMAX
SCHEMBL194498 0.84 CRHBP (1.00) CRHBPCRHR2NAT1MYCMAX

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 567 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117929342-A Application of p-dimethylaminobenzylidene rhodanine-sepiolite framework material in detection of mercury ions in acidic environment 中国科学院南京土壤研究所 2024-04-26 CN claimed
US-20230384188-A1 ROOM TEMPERATURE STABLE, DRY BIOLOGICAL TRANSPORT MEDIA GENTEGRA, LLC 2023-11-30 US claimed
EP-4199715-A1 ROOM TEMPERATURE STABLE, DRY BIOLOGICAL TRANSPORT MEDIA GenTegra LLC (US) 2023-06-28 EP claimed
CN-115337908-B Sepiolite-loaded p-dimethylaminobenzylidene rhodamine composite material and preparation method and application thereof 中国科学院南京土壤研究所 2023-05-26 CN claimed
EP-3252040-B1 STABILIZER FOR PRESERVING BIOLOGICAL SAMPLES BGI SHENZHEN (CN) 2023-04-19 EP claimed
US-11382868-B2 Transdermal UV-curable hydrogel resin, hydrogel curing the same and cataplasm containing the same ICURE PHARMACEUTICAL INC. (KR) 2022-07-12 US claimed
WO-2022040571-A1 ROOM TEMPERATURE STABLE, DRY BIOLOGICAL TRANSPORT MEDIA GENTEGRA, LLC (US) 2022-02-24 WO claimed
CN-112285270-A Method for determining total cyanide in water containing hydrogen peroxide 长春黄金研究院有限公司 2021-01-29 CN claimed
CN-107167472-B The rapid assay methods of total cyanide in a kind of ore pulp containing cyanogen 长春黄金研究院 2019-12-03 CN claimed
US-10494661-B2 Stabilizer for preserving biological samples BGI SHENZHEN (CN) 2019-12-03 US claimed
EP-1157431-A1 A HYBRID ELECTRICAL DEVICE WITH BIOLOGICAL COMPONENTS YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) 2001-11-28 EP claimed
WO-2000051191-A1 A HYBRID ELECTRICAL DEVICE WITH BIOLOGICAL COMPONENTS YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) 2000-08-31 WO claimed
EP-0915090-A1 Compounds useful as hypoglycemic agents and for treating Alzheimer's disease ELI LILLY AND COMPANY (US) 1999-05-12 EP claimed
US-5523314-A RHODANINE DERIVATIVES ELI LILLY AND COMPANY (US) 1996-06-04 US claimed
CN-1091006-A Chemical compound as blood sugar lowering and treatment degenerative brain disorder LILLY CO ELI (US) 1994-08-24 CN claimed
EP-0587377-A2 Thiazolidinone derivatives as hypoglycemic agents and for treating Alzheimer's disease ELI LILLY AND COMPANY (US) 1994-03-16 EP claimed
EP-0433677-A1 Removal of mercury from liquid hydrocarbons CALGON CARBON CORPORATION (US) 1991-06-26 EP claimed
US-4436999-A IN DIELECTRIC COATINGS OF SEMICONDUCTORS BY FLUORESCENCE RCA CORPORATION (US) 1984-03-13 US claimed
US-4345470-A All plastic disposable thermometer AKZONA INCORPORATED (US) 1982-08-24 US claimed
US-4232552-A THERMOCHROMISM, DISPOSABLE THERMOMETERS AKZONA INCORPORATED (US) 1980-11-11 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10494661-B2 Stabilizer for preserving biological samples NEFM, TREH, RNASE1 CRHBP 648/4885CRHR2 2684/4885PIM1 1293/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.