Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 8/20 | 0.36 |
| ▸ | RAB9A | P51151 | 7/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19253526 | 0.78 | NPSR1 (0.39) | CYP1A2CYP2D6CYP2C19NPSR1ADORA2A | |
| SCHEMBL28971658 | 0.78 | LMNA (0.43) | CYP1A2CYP2C19ADORA3NPC1RAB9A | |
| SCHEMBL358469 | 0.68 | CYP2C9 (0.47) | CYP1A2CYP2D6CYP2C19NPSR1NPC1 | |
| SCHEMBL19300141 | 0.67 | NPSR1 (0.38) | CYP1A2CYP2D6CYP2C19NPSR1ADORA2A | |
| SCHEMBL19253406 | 0.67 | NPC1 (0.39) | CYP1A2CYP2D6CYP2C19NPSR1ADORA2A | |
| SCHEMBL15229822 | 0.67 | PDE4A (0.40) | ADORA2AADORA3ADORA1NPC1RAB9A | |
| SCHEMBL17007856 | 0.66 | ALDH1A1 (0.36) | CYP1A2NPSR1ADORA2AADORA3ADORA1 | |
| SCHEMBL15230894 | 0.64 | MAPK1 (0.40) | NPC1RAB9AALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL24060877 | 0.64 | NPC1 (0.38) | CYP1A2CYP2D6CYP2C19NPSR1ADORA2A | |
| SCHEMBL3676305 | 0.64 | ADORA2A (0.54) | CYP1A2CYP2D6CYP2C19NPSR1ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230045252-A1 | PYRAZOLO[1,5-A]PYRAZIN-4-YL DERIVATIVES | PFIZER INC. (US) | 2023-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230045252-A1 | PYRAZOLO[1,5-A]PYRAZIN-4-YL DERIVATIVES | CBR3, CNR1, CCR6 | CYP1A2 1267/4885CYP2D6 20/4885CYP2C19 1151/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.