Sugi Predict

Sugi Predict / Compounds / SCHEMBL2499765

SCHEMBL2499765

SCHEMBL2499765

CCNc1cc(C)ccc1C

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CYP3A4 P08684 1/20 0.64
▸ TSHR P16473 1/20 0.64
▸ RECQL P46063 1/20 0.64
▸ HTT P42858 2/20 0.50
▸ RAPGEF4 Q8WZA2 1/20 0.50
▸ ALDH1A1 P00352 5/20 0.49
▸ GAA P10253 4/20 0.49
▸ LMNA P02545 2/20 0.49
▸ GUCY1A1 Q02108 1/20 0.46
▸ GUCY1B1 Q02153 1/20 0.46
▸ MAPT P10636 1/20 0.46
▸ NLRP3 Q96P20 1/20 0.45
▸ KDM4E B2RXH2 1/20 0.44
▸ KMT2A Q03164 2/20 0.44
▸ MEN1 O00255 1/20 0.44
▸ HDAC3 O15379 1/20 0.42
▸ HDAC4 P56524 1/20 0.42
▸ HDAC1 Q13547 1/20 0.42
▸ HDAC7 Q8WUI4 1/20 0.42
▸ HDAC2 Q92769 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9363410 0.84 RAPGEF4 (0.52) CYP3A4TSHRRECQLHTTRAPGEF4
SCHEMBL7536862 0.83 GUCY1A1 (0.51) CYP3A4TSHRRECQLHTTRAPGEF4
SCHEMBL8348988 0.82 RAPGEF4 (0.52) CYP3A4TSHRRECQLHTTRAPGEF4
Hydrochloric Acid SCHEMBL21248268 0.81 GUCY1A1 (0.50) CYP3A4TSHRRECQLHTTRAPGEF4
SCHEMBL1485822 0.80 RECQL (0.62) CYP3A4TSHRRECQLHTTALDH1A1
SCHEMBL13204732 0.80 HTT (0.53) CYP3A4TSHRRECQLHTTRAPGEF4
SCHEMBL24131528 0.78 TSHR (0.41) CYP3A4TSHRRECQLHTTRAPGEF4
SCHEMBL21812018 0.78 TSHR (0.60) CYP3A4TSHRRECQLHTTALDH1A1
SCHEMBL1645546 0.78 TSHR (0.60) CYP3A4TSHRRECQLHTTRAPGEF4
SCHEMBL20707057 0.78 CYP1A2 (0.42) CYP3A4TSHRRECQLHTTRAPGEF4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 49 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230136150-A1 Compositions for Inhibition of Insect Sensing UNIV VANDERBILT (US) 2023-05-04 — — US disclosed
US-20210219551-A1 Compositions for Inhibition of Insect Sensing VANDERBILT UNIVERSITY 2021-07-22 — — US disclosed
US-10813355-B2 Compositions for inhibition of insect sensing VANDERBILT UNIVERSITY (US) 2020-10-27 — — US disclosed
US-20190075798-A1 Compositions for Inhibition of Insect Sensing VANDERBILT UNIVERSITY 2019-03-14 — — US disclosed
EP-3345907-A1 NOVEL PYRAZOLO[3,4-d]PYRIMIDINE COMPOUND OR SALT THEREOF Taiho Pharmaceutical Co., Ltd. (JP) 2018-07-11 — — EP disclosed
US-20160045528-A1 COMBINATION THERAPY FOR TREATING A PARAMYXOVIRUS ALIOS BIOPHARMA, INC. 2016-02-18 — — US disclosed
US-20160045528-A1 COMBINATION THERAPY FOR TREATING A PARAMYXOVIRUS ALIOS BIOPHARMA, INC. 2016-02-18 — — US disclosed
WO-2016022464-A1 COMBINATION THERAPY FOR TREATING A PARAMYXOVIRUS ALIOS BIOPHARMA, INC. (US) 2016-02-11 — — WO disclosed
CN-102975508-B Reversible thermosensitive recording medium RICOH CO LTD 2014-12-03 — — CN disclosed
US-8883837-B2 Morpholinyl containing benzimidazoles as inhibitors of respiratory syncytial virus replication JANSSEN PHARMACEUTICA NV (BE) 2014-11-11 — — US disclosed
US-20040005607-A1 Non-fluorescent quencher compounds and biomolecular assays APPLIED BIOSYSTEMS, LLC 2004-01-08 — — US disclosed
US-20030082547-A1 Non-fluorescent quencher compounds and biomolecular assays APPLIED BIOSYSTEMS, LLC 2003-05-01 — — US disclosed
WO-2003019145-A2 NON-FLUORESCENT QUENCHER COMPOUNDS AND BIOMOLECULAR ASSAYS APPLERA CORPORATION (US) 2003-03-06 — — WO disclosed
CN-1057552-C Triphenodioxazine dyes and preparation and application of same ZENECA LTD (GB) 2000-10-18 — — CN disclosed
EP-0576123-B1 Watersoluble triphenodioxazine dye AVECIA LTD (GB) 2000-03-01 — — EP disclosed
EP-0428482-B1 Reactive dyes, process for their preparation and their use CIBA GEIGY AG (CH) 1995-05-31 — — EP disclosed
EP-0576123-A1 Watersoluble triphenodioxazine dye ZENECA LIMITED (GB) 1993-12-29 — — EP disclosed
US-5136028-A Red; colorfastness CIBA-GEIGY CORPORATION (US) 1992-08-04 — — US disclosed
EP-0428482-A1 Reactive dyes, process for their preparation and their use CIBA-GEIGY AG (CH) 1991-05-22 — — EP disclosed
US-3992405-A ESPECIALLY FOR DYEING POLYACRYLIC FIBERS BAYER AKTIENGESELLSCHAFT (DT) 1976-11-16 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230136150-A1 Compositions for Inhibition of Insect Sensing OR51E2, TRPA1, OR10J3 CYP3A4 3922/4885TSHR 2971/4885RECQL 4067/4885
US-10813355-B2 Compositions for inhibition of insect sensing OR51E2, TRPA1, OR10J3 CYP3A4 3964/4885TSHR 3088/4885RECQL 3986/4885
US-20030082547-A1 Non-fluorescent quencher compounds and biomolecular assays DNTT, PNP, NT5C2 CYP3A4 864/4885TSHR 1442/4885RECQL 376/4885
US-20160045528-A1 COMBINATION THERAPY FOR TREATING A PARAMYXOVIRUS MAVS, EIF2AK2, SARS1 CYP3A4 4543/4885TSHR 3851/4885RECQL 1171/4885
US-20210219551-A1 Compositions for Inhibition of Insect Sensing OR51E2, TRPA1, OR10J3 CYP3A4 3922/4885TSHR 2971/4885RECQL 4067/4885
US-20040005607-A1 Non-fluorescent quencher compounds and biomolecular assays DNTT, PNP, NT5C2 CYP3A4 864/4885TSHR 1442/4885RECQL 376/4885
US-20190075798-A1 Compositions for Inhibition of Insect Sensing OR51E2, TRPA1, OR10J3 CYP3A4 3964/4885TSHR 3088/4885RECQL 3986/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.