Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 11/20 | 0.59 |
| ▸ | BTK | Q06187 | 1/20 | 0.59 |
| ▸ | ULK1 | O75385 | 3/20 | 0.46 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.45 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.45 |
| ▸ | TTK | P33981 | 1/20 | 0.44 |
| ▸ | AXL | P30530 | 1/20 | 0.41 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.41 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.41 |
| ▸ | INSR | P06213 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23441671 | 0.92 | EGFR (0.51) | EGFRBTKULK1ALKCDK19 | |
| SCHEMBL23441991 | 0.92 | EGFR (0.71) | EGFRBTKALKINSRJAK2 | |
| Hydrochloric Acid SCHEMBL29094608 | 0.91 | EGFR (0.50) | EGFRBTKALKCDK19TTK | |
| SCHEMBL23441888 | 0.90 | EGFR (0.61) | EGFRBTK | |
| SCHEMBL23420454 | 0.89 | EGFR (0.67) | EGFRBTKULK1MAP4K1 | |
| SCHEMBL23442003 | 0.89 | EGFR (0.61) | EGFRBTKALKINSR | |
| Trifluoroacetic Acid SCHEMBL29094594 | 0.86 | EGFR (0.47) | EGFRBTKULK1ALKCDK19 | |
| SCHEMBL25001890 | 0.86 | EGFR (0.55) | EGFRBTKTTK | |
| SCHEMBL25001951 | 0.85 | EGFR (0.66) | EGFRBTKULK1ALKCDK19 | |
| SCHEMBL25001626 | 0.85 | EGFR (0.56) | EGFRBTKULK1ALKCDK19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021104441-A1 | POLYAROMATIC COMPOUND AS EGFR KINASE INHIBITOR | 江苏先声药业有限公司 | 2021-06-03 | — | — | WO | disclosed |