Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 18/20 | 0.57 |
| ▸ | PLK1 | P53350 | 1/20 | 0.45 |
| ▸ | BTK | Q06187 | 1/20 | 0.43 |
| ▸ | INSR | P06213 | 1/20 | 0.42 |
| ▸ | IGF1R | P08069 | 1/20 | 0.42 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25002853 | 0.90 | EGFR (0.47) | EGFRBTKALK | |
| SCHEMBL25002442 | 0.90 | EGFR (0.54) | EGFRBTKINSRALK | |
| SCHEMBL25001448 | 0.89 | EGFR (0.58) | EGFRPLK1BTKINSRIGF1R | |
| SCHEMBL25001715 | 0.86 | EGFR (0.61) | EGFRPLK1BTKINSRIGF1R | |
| SCHEMBL29084096 | 0.84 | EGFR (0.71) | EGFRPLK1BTKINSRIGF1R | |
| SCHEMBL25001656 | 0.83 | EGFR (0.48) | EGFRBTKINSRALK | |
| SCHEMBL30860746 | 0.82 | EGFR (0.54) | EGFRPLK1BTK | |
| SCHEMBL25001450 | 0.82 | EGFR (0.46) | EGFRPLK1INSRIGF1RALK | |
| SCHEMBL30860273 | 0.82 | EGFR (0.53) | EGFRBTK | |
| SCHEMBL30860759 | 0.81 | EGFR (0.56) | EGFRBTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4129996-A1 | NOVEL AMINOPYRIMIDINE EGFR INHIBITOR | QILU PHARMACEUTICAL CO., LTD. (CN) | 2023-02-08 | — | — | EP | disclosed |