Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.66 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.66 |
| ▸ | HPGD | P15428 | 5/20 | 0.66 |
| ▸ | GAA | P10253 | 1/20 | 0.66 |
| ▸ | RAB9A | P51151 | 2/20 | 0.60 |
| ▸ | CTSV | O60911 | 2/20 | 0.52 |
| ▸ | CTSL | P07711 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.51 |
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3284596 | 0.82 | KDM4E (0.79) | KDM4EALDH1A1HSD17B10HPGDGAA | |
| SCHEMBL27743122 | 0.81 | KDM4E (0.56) | KDM4EALDH1A1HSD17B10HPGDGAA | |
| SCHEMBL1900540 | 0.81 | KDM4E (0.80) | KDM4EALDH1A1HSD17B10HPGDGAA | |
| SCHEMBL2754183 | 0.79 | KDM4E (1.00) | KDM4EALDH1A1HSD17B10HPGDGAA | |
| SCHEMBL29722594 | 0.79 | RAB9A (0.77) | KDM4EALDH1A1HSD17B10HPGDGAA | |
| SCHEMBL15338397 | 0.79 | RAB9A (0.77) | KDM4EALDH1A1HSD17B10HPGDGAA | |
| SCHEMBL12204302 | 0.78 | KDM4E (1.00) | KDM4EALDH1A1HSD17B10HPGDGAA | |
| SCHEMBL4921978 | 0.78 | KDM4E (0.70) | KDM4EALDH1A1HSD17B10HPGDGAA | |
| SCHEMBL8440798 | 0.76 | KDM4E (0.68) | KDM4EALDH1A1HSD17B10HPGDGAA | |
| SCHEMBL8444672 | 0.76 | KDM4E (0.68) | KDM4EALDH1A1HSD17B10HPGDGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888558-B1 | BICYCLIC DERIVATIVES AS MODULATORS OF ION CHANNELS | VERTEX PHARMA (US) | 2011-10-05 | — | — | EP | disclosed |
| WO-2005008249-A1 | AUTISM SCREENING TEST, METHOD OF SELECTING PATIENTS THAT RESPOND TO SAID TEST AND USE OF BKCA CHANNEL ACTIVATOR MEDICAMENTS FOR THE TREATMENT OF AUTISM | UNIVERSITE FRANCOIS RABELAIS (FR) | 2005-01-27 | — | — | WO | disclosed |
| US-20030211547-A1 | Large conductance calcium-dependent potassium channel as modulator of alcohol effects and consumption | MCINTIRE STEVEN L (US) | 2003-11-13 | — | — | US | disclosed |
| EP-1011677-A4 | 4-ARYL-3-AMINOQUINOLINE-2-ONE DERIVATIVES AS POTASSIUM CHANNEL MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2002-03-20 | — | — | EP | disclosed |
| EP-1011677-A4 | 4-ARYL-3-AMINOQUINOLINE-2-ONE DERIVATIVES AS POTASSIUM CHANNEL MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2002-03-20 | — | — | EP | disclosed |
| WO-2001094375-A1 | LARGE CONDUCTANCE CALCIUM-DEPENDENT POTASSIUM CHANNEL AS MODULATOR OF ALCOHOL EFFECTS AND CONSUMPTION | MCINTIRE STEVEN L (US) | 2001-12-13 | — | — | WO | disclosed |
| EP-1011677-A1 | 4-ARYL-3-AMINOQUINOLINE-2-ONE DERIVATIVES AS POTASSIUM CHANNEL MODULATORS | Bristol-Myers Squibb Company (US) | 2000-06-28 | — | — | EP | disclosed |
| EP-1011677-A1 | 4-ARYL-3-AMINOQUINOLINE-2-ONE DERIVATIVES AS POTASSIUM CHANNEL MODULATORS | Bristol-Myers Squibb Company (US) | 2000-06-28 | — | — | EP | disclosed |
| US-5972961-A | ANTIISCHEMIC AGENTS; ANTICONVULSANTS; HEADACHES; SEXUAL DISORDERS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-10-26 | — | — | US | disclosed |
| US-5972961-A | ANTIISCHEMIC AGENTS; ANTICONVULSANTS; HEADACHES; SEXUAL DISORDERS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-10-26 | — | — | US | disclosed |
| US-5972961-A | ANTIISCHEMIC AGENTS; ANTICONVULSANTS; HEADACHES; SEXUAL DISORDERS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-10-26 | — | — | US | disclosed |
| WO-1999009983-A1 | 4-ARYL-3-AMINOQUINOLINE-2-ONE DERIVATIVES AS POTASSIUM CHANNEL MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-03-04 | — | — | WO | disclosed |
| WO-1999009983-A1 | 4-ARYL-3-AMINOQUINOLINE-2-ONE DERIVATIVES AS POTASSIUM CHANNEL MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-03-04 | — | — | WO | disclosed |