Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | MMP13 | P45452 | 1/20 | 0.46 |
| ▸ | MMP14 | P50281 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MITF | O75030 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3713517 | 0.88 | NPC1 (0.54) | RAB9ASMN1; SMN2MAPTNPC1PKM | |
| SCHEMBL25002910 | 0.86 | FDPS (0.50) | RAB9AMAPTNPC1MMP2MMP13 | |
| SCHEMBL25002921 | 0.86 | ABL1 (0.50) | MAPTMMP2MMP13MMP14 | |
| SCHEMBL24572143 | 0.85 | GABRA2 (0.53) | RAB9ASMN1; SMN2MAPTMAPK1NPC1 | |
| SCHEMBL25002932 | 0.85 | GABRA2 (0.53) | RAB9ASMN1; SMN2MAPTNPC1MMP2 | |
| SCHEMBL8126380 | 0.85 | CYP1A2 (0.51) | RAB9ASMN1; SMN2MAPTMAPK1NPC1 | |
| SCHEMBL311880 | 0.84 | CYP1A2 (0.50) | RAB9ASMN1; SMN2HSP90AA1MAPTMAPK1 | |
| Hydrochloric Acid SCHEMBL8124072 | 0.84 | GABRA2 (0.50) | RAB9ASMN1; SMN2MAPTMAPK1NPC1 | |
| SCHEMBL15530701 | 0.83 | MMP2 (0.44) | RAB9ASMN1; SMN2HSP90AA1MAPTNPC1 | |
| SCHEMBL3714078 | 0.81 | SMPD1 (0.51) | RAB9ASMN1; SMN2MAPTNPC1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023010192-A1 | N-ACYLHYDRAZONE COMPOUNDS CAPABLE OF INHIBITING NAV1.7 AND/OR NAV1.8, PROCESSES FOR THE PREPARATION THEREOF, COMPOSITIONS, USES, METHODS FOR TREATMENT USING SAME, AND KITS | EUROFARMA LABORATÓRIOS S.A. (BR) | 2023-02-09 | — | — | WO | disclosed |