Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.52 |
| ▸ | CTSA | P10619 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | ALPL | P05186 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | PARP1 | P09874 | 1/20 | 0.50 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.50 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.49 |
| ▸ | CASP7 | P55210 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1179838 | 0.88 | CYP11B1 (0.56) | KDM4EGAAMAPTNPC1LMNA | |
| SCHEMBL3711274 | 0.87 | MCL1 (0.55) | GAAMAPTSMN1; SMN2SCN9AALDH1A1 | |
| SCHEMBL483444 | 0.86 | MAPT (0.56) | GAAMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL28473632 | 0.86 | PARP1 (0.51) | ADORA3CTSAKDM4EGAAKMT2A | |
| SCHEMBL30614602 | 0.86 | MCL1 (0.60) | ADORA3CTSAKDM4EGAAKMT2A | |
| SCHEMBL4630405 | 0.86 | MCL1 (0.60) | ADORA3CTSAKDM4EGAAKMT2A | |
| SCHEMBL25002893 | 0.85 | NPC1 (0.55) | ADORA3CTSAKDM4EMAPTNPC1 | |
| SCHEMBL4591255 | 0.85 | SCN10A (0.65) | ADORA3KDM4EMAPTSCN9AALDH1A1 | |
| SCHEMBL25002928 | 0.85 | MCL1 (0.54) | CTSAKDM4EGAAKMT2AMAPT | |
| SCHEMBL1260197 | 0.85 | ALDH1A1 (0.52) | ADORA3KDM4EGAAKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023010192-A1 | N-ACYLHYDRAZONE COMPOUNDS CAPABLE OF INHIBITING NAV1.7 AND/OR NAV1.8, PROCESSES FOR THE PREPARATION THEREOF, COMPOSITIONS, USES, METHODS FOR TREATMENT USING SAME, AND KITS | EUROFARMA LABORATÓRIOS S.A. (BR) | 2023-02-09 | — | — | WO | disclosed |