Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | SCN2A | Q99250 | 3/20 | 0.50 |
| ▸ | SCN10A | Q9Y5Y9 | 3/20 | 0.50 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.48 |
| ▸ | GRM5 | P41594 | 1/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | MITF | O75030 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | FAAH | O00519 | 1/20 | 0.46 |
| ▸ | CTSA | P10619 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | AHR | P35869 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25002917 | 0.89 | PLA2G2A (0.54) | NPC1RAB9ASCN9AKDM4EALDH1A1 | |
| SCHEMBL25003937 | 0.89 | PLA2G2A (0.58) | NPC1RAB9ASCN9AKDM4EALDH1A1 | |
| SCHEMBL22940145 | 0.86 | PLA2G2A (0.55) | NPC1SMN1; SMN2LMNACYP1A2MAPT | |
| SCHEMBL29660380 | 0.86 | KDM4E (0.55) | NPC1RAB9ASCN2ASCN10AADORA3 | |
| SCHEMBL22939955 | 0.86 | ADORA3 (0.50) | NPC1RAB9ASCN2ASCN10ASCN9A | |
| SCHEMBL25002929 | 0.85 | ADORA3 (0.52) | NPC1RAB9ASCN10ASCN9AADORA3 | |
| SCHEMBL22939576 | 0.85 | CYP1A2 (0.50) | NPC1RAB9ASCN2ASCN10AADORA3 | |
| SCHEMBL25003805 | 0.85 | ALDH1A1 (0.57) | NPC1RAB9ASCN2ASCN10ASCN9A | |
| SCHEMBL3129112 | 0.84 | KDM4E (0.55) | SCN9AKDM4EALDH1A1HPGDMAPT | |
| SCHEMBL3712561 | 0.84 | MCL1 (0.59) | NPC1RAB9ASMN1; SMN2FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023010192-A1 | N-ACYLHYDRAZONE COMPOUNDS CAPABLE OF INHIBITING NAV1.7 AND/OR NAV1.8, PROCESSES FOR THE PREPARATION THEREOF, COMPOSITIONS, USES, METHODS FOR TREATMENT USING SAME, AND KITS | EUROFARMA LABORATÓRIOS S.A. (BR) | 2023-02-09 | — | — | WO | disclosed |