Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.54 |
| ▸ | MAPT | P10636 | 6/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 5/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | IKBKB | O14920 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | CLK1 | P49759 | 1/20 | 0.47 |
| ▸ | CLK2 | P49760 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25003151 | 0.88 | ALDH1A1 (0.57) | ALDH1A1MAPTLMNAMEN1KMT2A | |
| SCHEMBL25003141 | 0.85 | KMO (0.48) | ALDH1A1MAPTLMNAMEN1KMT2A | |
| SCHEMBL25003132 | 0.85 | CYP2D6 (0.50) | ALDH1A1MAPTLMNAMEN1KMT2A | |
| SCHEMBL25003143 | 0.85 | MEN1 (0.48) | ALDH1A1MAPTLMNAMEN1KMT2A | |
| SCHEMBL25002894 | 0.84 | KMT2A (0.56) | ALDH1A1MAPTLMNAMEN1KMT2A | |
| SCHEMBL25003145 | 0.83 | KMT2A (0.48) | MAPTMEN1KMT2AKDM4EGAA | |
| SCHEMBL25003139 | 0.81 | KMO (0.68) | ALDH1A1MAPTLMNAMEN1KMT2A | |
| SCHEMBL30489168 | 0.81 | MEN1 (0.69) | MEN1KMT2ANPC1RAB9AKMO | |
| SCHEMBL3133736 | 0.81 | MAPT (0.52) | ALDH1A1MAPTLMNAMEN1KMT2A | |
| SCHEMBL25003144 | 0.80 | KMO (0.51) | ALDH1A1LMNAMEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023010192-A1 | N-ACYLHYDRAZONE COMPOUNDS CAPABLE OF INHIBITING NAV1.7 AND/OR NAV1.8, PROCESSES FOR THE PREPARATION THEREOF, COMPOSITIONS, USES, METHODS FOR TREATMENT USING SAME, AND KITS | EUROFARMA LABORATÓRIOS S.A. (BR) | 2023-02-09 | — | — | WO | disclosed |