Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 5/20 | 0.81 |
| ▸ | MAPT | P10636 | 2/20 | 0.81 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.74 |
| ▸ | HTT | P42858 | 1/20 | 0.74 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | PKM | P14618 | 7/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | THRB | P10828 | 3/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25009491 | 0.83 | ALDH1A1 (0.72) | TP53MAPTALDH1A1HTTMEN1 | |
| SCHEMBL25009511 | 0.78 | MEN1 (1.00) | TP53MAPTALDH1A1HTTMEN1 | |
| SCHEMBL25009094 | 0.76 | POLB (0.66) | TP53MAPTALDH1A1HTTMEN1 | |
| SCHEMBL25010891 | 0.76 | POLB (0.63) | TP53MAPTALDH1A1HTTMEN1 | |
| SCHEMBL25009502 | 0.75 | MEN1 (0.81) | TP53MAPTALDH1A1HTTMEN1 | |
| SCHEMBL18184455 | 0.74 | TP53 (0.67) | TP53MAPTALDH1A1HTTMEN1 | |
| SCHEMBL25010896 | 0.74 | PKM (0.79) | TP53PKMPOLBTHRBLMNA | |
| SCHEMBL16032121 | 0.73 | TP53 (0.66) | TP53MAPTMEN1KMT2APKM | |
| SCHEMBL24809087 | 0.72 | TP53 (0.64) | TP53MAPTALDH1A1HTTMEN1 | |
| SCHEMBL18184511 | 0.72 | TP53 (0.64) | TP53MAPTMEN1KMT2APKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230041576-A1 | METHODS AND MATERIALS FOR INHIBITING NF-kB ACTIVITY | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2023-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230041576-A1 | METHODS AND MATERIALS FOR INHIBITING NF-kB ACTIVITY | NFKBIA, IKBKB, NFKB2 | TP53 376/4885MAPT 2111/4885ALDH1A1 4286/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.