Dioxifedrine

Dioxifedrine

SCHEMBL250137

CNC(C)C(O)c1ccc(O)c(O)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TDP1 Q9NUW8 9/20 0.61
▸ KDM4E B2RXH2 9/20 0.61
▸ MAPT P10636 8/20 0.61
▸ RECQL P46063 5/20 0.61
▸ KMT2A Q03164 5/20 0.61
▸ TSHR P16473 5/20 0.61
▸ HSD17B10 Q99714 5/20 0.61
▸ MTOR P42345 4/20 0.61
▸ LMNA P02545 3/20 0.61
▸ NFKB1 P19838 3/20 0.61
▸ HIF1A Q16665 3/20 0.61
▸ BLM P54132 3/20 0.61
▸ ALOX15 P16050 2/20 0.61
▸ THPO P40225 2/20 0.61
▸ APEX1 P27695 2/20 0.61
▸ POLB P06746 2/20 0.61
▸ ADRA1A P35348 3/20 0.55
▸ CYP3A4 P08684 3/20 0.55
▸ CYP2D6 P10635 2/20 0.55
▸ ALOX12 P18054 2/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Dioxifedrine SCHEMBL364347 0.98 KDM4E (0.62) TDP1KDM4EMAPTRECQLKMT2A
SCHEMBL668000 0.85 KDM4E (0.61) TDP1KDM4EMAPTRECQLKMT2A
SCHEMBL10305119 0.84 ADRA2C (0.57) TDP1KDM4EMAPTRECQLKMT2A
SCHEMBL11279641 0.80 SLC6A4 (0.59) TDP1KDM4EMAPTRECQLKMT2A
Dioxethedrin SCHEMBL249560 0.80 ADRB2 (0.58) TDP1KDM4EMAPTRECQLKMT2A
Epinephrine SCHEMBL3904566 0.80 KDM4E (0.68) TDP1KDM4EMAPTRECQLKMT2A
SCHEMBL14290757 0.79 TDP1 (0.70) TDP1KDM4EMAPTRECQLKMT2A
Dioxethedrin SCHEMBL365011 0.79 KDM4E (0.57) TDP1KDM4EMAPTRECQLKMT2A
Hydrochloric Acid SCHEMBL11279633 0.79 KDM4E (0.57) TDP1KDM4EMAPTRECQLKMT2A
SCHEMBL29102057 0.79 TDP1 (0.68) TDP1KDM4EMAPTRECQLKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 173 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20180193209-A1 A POLYMER PRODUCT AND PREPARATION THEROF SINGAPORE HEALTH SERVICES PTE LTD. (SG) 2018-07-12 — — US claimed
EP-3319779-A1 A POLYMER PRODUCT AND PREPARATION THEREOF Singapore Health Services Pte Ltd (SG) 2018-05-16 — — EP claimed
CN-108025477-A Polymer products and their preparation 新加坡保健服务集团 2018-05-11 — — CN claimed
US-20150158809-A9 METHOD OF MAKING 1-(ACYLOXY)-ALKYL CARBAMATE COMPOUNDS XENOPORT, INC. (US) 2015-06-11 — — US claimed
US-9016221-B2 Surface topographies for non-toxic bioadhesion control UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2015-04-28 — — US claimed
US-20140243544-A1 METHOD OF MAKING 1-(ACYLOXY)-ALKYL CARBAMATE COMPOUNDS XENOPORT, INC. (US) 2014-08-28 — — US claimed
US-8299291-B2 Methods of synthesizing 1-(acyloxy)-alkyl carbamate prodrugs XENOPORT, INC. (US) 2012-10-30 — — US claimed
US-8062870-B2 Enantiomerically resolving acyloxyalkyl thiocarbonates used in synthesizing acyloxyalkyl carbamate prodrugs XENOPORT, INC. (US) 2011-11-22 — — US claimed
US-20100226943-A1 SURFACE TOPOGRAPHIES FOR NON-TOXIC BIOADHESION CONTROL UNIVERSITY OF FLORIDA (US) 2010-09-09 — — US claimed
CN-101330905-A Freeze-drying process and products obtained thereby SCIDOSE LLC (US) 2008-12-24 — — CN claimed
EP-1954244-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY Scidose, Llc (US) 2008-08-13 — — EP claimed
WO-2007061529-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY SCIDOSE LLC. (US) 2007-05-31 — — WO claimed
US-20070116729-A1 Lyophilization process and products obtained thereby SCIDOSE LLC 2007-05-24 — — US claimed
CN-1791437-A Medical implants comprising biocompatible coatings BLUE MEMBRANES GMBH (DE) 2006-06-21 — — CN claimed
WO-1994000432-A1 ANORECTIC EPINEPHRINE DERIVATIVES THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 1994-01-06 — — WO claimed
EP-2841109-B1 PRODRUGS OF HYDROXYL-COMPRISING DRUGS ASCENDIS PHARMA AS (DK) 2026-04-15 — — EP disclosed
EP-3782649-B1 BIODEGRADABLE POLYETHYLENE GLYCOL BASED WATER-INSOLUBLE HYDROGELS ASCENDIS PHARMA AS (DK) 2025-05-14 — — EP disclosed
EP-0167204-A1 Method for improving the absorption and effectiveness of a catecholamine compound SIMES S.p.A. Società Italiana Medicinali e Sintetici (IT) 1986-01-08 — — EP disclosed
US-4226803-A Process for production of optically active bases DEUTSCHE GOLD- UND SILBER-SCHEIDEANSTALT VORMALS ROESSLER (DE) 1980-10-07 — — US disclosed
US-4191777-A Maleic acid halfamides having blood pressure raising activity DEUTSCHE GOLD- UND SILBER-SCHEIDEANSTALT VORMALS ROESSLER (DE) 1980-03-04 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150158809-A9 METHOD OF MAKING 1-(ACYLOXY)-ALKYL CARBAMATE COMPOUNDS CPS1, CA7, NAAA TDP1 890/4885KDM4E 180/4885MAPT 3200/4885
US-20140243544-A1 METHOD OF MAKING 1-(ACYLOXY)-ALKYL CARBAMATE COMPOUNDS CPS1, CA7, NAAA TDP1 890/4885KDM4E 180/4885MAPT 3200/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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