Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 12/20 | 0.39 |
| ▸ | CA9 | Q16790 | 12/20 | 0.39 |
| ▸ | CA2 | P00918 | 9/20 | 0.36 |
| ▸ | CA1 | P00915 | 5/20 | 0.36 |
| ▸ | CA7 | P43166 | 4/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22011242 | 0.88 | NLRP3 (0.41) | KMT2AMEN1CA12CA9CA2 | |
| SCHEMBL22011241 | 0.88 | NLRP3 (0.41) | KMT2AMEN1CA12CA9CA2 | |
| SCHEMBL16419114 | 0.83 | CA12 (0.57) | NPC1ALDH1A1PLA2G1BNFKB1CASP3 | |
| SCHEMBL22011237 | 0.78 | CA12 (0.47) | ALDH1A1RELAKMT2AMEN1CA12 | |
| SCHEMBL25014631 | 0.75 | CA12 (0.38) | KMT2ACA12CA9CA2CA1 | |
| SCHEMBL25014902 | 0.75 | CHEK1 (0.59) | ALDH1A1RELAKMT2ACA12CA9 | |
| SCHEMBL22010260 | 0.75 | CA9 (0.47) | KMT2ACA12CA9CA2CA1 | |
| SCHEMBL22010623 | 0.74 | MAOA (0.44) | NPC1ALDH1A1RAB9AL3MBTL1KMT2A | |
| SCHEMBL16283453 | 0.73 | CHEK1 (0.57) | NPC1ALDH1A1PLA2G1BNFKB1CASP3 | |
| SCHEMBL22011240 | 0.72 | KMT2A (0.47) | ALDH1A1CASP3KMT2AMEN1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230024859-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS AG (CH) | 2023-01-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230024859-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NLRP1, NLRP3, NOD1 | NPC1 46/4885ALDH1A1 2065/4885PLA2G1B 1655/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.