Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 3/20 | 0.46 |
| ▸ | CES1 | P23141 | 1/20 | 0.46 |
| ▸ | NR1H3 | Q13133 | 7/20 | 0.42 |
| ▸ | NR1H2 | P55055 | 5/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | GABRP | O00591 | 1/20 | 0.38 |
| ▸ | GABRD | O14764 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18272794 | 0.85 | TTR (0.49) | TTRCES1NR1H3NR1H2CASP3 | |
| SCHEMBL25132883 | 0.82 | TTR (0.45) | TTRCES1NR1H3NR1H2CASP3 | |
| SCHEMBL18272795 | 0.79 | TTR (0.49) | TTRCES1NR1H3NR1H2CASP3 | |
| SCHEMBL25129541 | 0.76 | TTR (0.45) | TTRCES1NR1H3NR1H2CASP3 | |
| SCHEMBL23422767 | 0.73 | TDO2 (0.46) | CES1MEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL16127516 | 0.72 | TTR (0.75) | TTRCES1NR1H3NR1H2CASP3 | |
| SCHEMBL26241240 | 0.70 | ALDH1A1 (0.33) | ALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL20151894 | 0.69 | ALDH1A1 (0.44) | MEN1ALDH1A1MAPTHPGDKMT2A | |
| SCHEMBL12059596 | 0.69 | TTR (0.69) | TTRCES1NR1H3NR1H2CASP3 | |
| SCHEMBL25129809 | 0.68 | TOP2A (0.43) | ALDH1A1MAPTKMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023014988-A1 | CONJUGATES COMPRISING COVALENT BINDERS FOR TARGETING INTRACELLULAR PROTEINS | RAYZEBIO, INC. (US) | 2023-02-09 | — | — | WO | disclosed |