Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 8/20 | 0.41 |
| ▸ | TSHR | P16473 | 7/20 | 0.41 |
| ▸ | HPGD | P15428 | 6/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | CRHBP | P24387 | 1/20 | 0.34 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | ATP2A2 | P16615 | 1/20 | 0.33 |
| ▸ | ATP2A3 | Q93084 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25015442 | 0.82 | ALDH1A1 (0.40) | HSD17B10TSHRHPGDCYP3A4ALDH1A1 | |
| SCHEMBL25008862 | 0.81 | HSD17B10 (0.52) | HSD17B10TSHRHPGDCYP3A4HSP90AA1 | |
| SCHEMBL9115158 | 0.77 | HSD17B10 (0.46) | HSD17B10TSHRHPGDCYP3A4HSP90AA1 | |
| SCHEMBL6232540 | 0.75 | HSD17B10 (0.44) | HSD17B10TSHRHPGDCYP3A4HSP90AA1 | |
| SCHEMBL24945814 | 0.73 | ALDH1A1 (0.34) | HSD17B10HPGDALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL24069516 | 0.73 | CYP3A4 (0.38) | HSD17B10TSHRHPGDCYP3A4ALDH1A1 | |
| SCHEMBL7682433 | 0.73 | HSD17B10 (0.52) | HSD17B10TSHRHPGDCYP3A4HSP90AA1 | |
| SCHEMBL22468667 | 0.72 | ALDH1A1 (0.37) | HSD17B10HPGDALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL21792618 | 0.72 | CYP3A4 (0.38) | HSD17B10TSHRHPGDCYP3A4ALDH1A1 | |
| SCHEMBL23542368 | 0.71 | HSD17B10 (0.39) | HSD17B10TSHRHPGDCYP3A4HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230023559-A1 | ARYLMETHYLENE HETEROCYCLIC COMPOUNDS AS KV1.3 POTASSIUM SHAKER CHANNEL BLOCKERS | D. E. SHAW RESEARCH, LLC (US) | 2023-01-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230023559-A1 | ARYLMETHYLENE HETEROCYCLIC COMPOUNDS AS KV1.3 POTASSIUM SHAKER CHANNEL BLOCKERS | KCNJ2, KCNA3, KCNH3 | HSD17B10 715/4885TSHR 1969/4885HPGD 2590/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.