Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 11/20 | 0.52 |
| ▸ | TSHR | P16473 | 10/20 | 0.52 |
| ▸ | HPGD | P15428 | 7/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.52 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.34 |
| ▸ | RECQL | P46063 | 2/20 | 0.34 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9115158 | 0.78 | HSD17B10 (0.46) | HSD17B10TSHRHPGDCYP3A4HSP90AA1 | |
| SCHEMBL11872648 | 0.75 | CYP3A4 (0.50) | HSD17B10TSHRHPGDCYP3A4HSP90AA1 | |
| SCHEMBL9643418 | 0.74 | CYP3A4 (0.56) | HSD17B10TSHRHPGDCYP3A4HSP90AA1 | |
| SCHEMBL25015441 | 0.73 | HSD17B10 (0.41) | HSD17B10TSHRHPGDCYP3A4HSP90AA1 | |
| SCHEMBL8761719 | 0.73 | HSD17B10 (0.41) | HSD17B10TSHRHPGDCYP3A4HSP90AA1 | |
| SCHEMBL1756490 | 0.72 | CYP3A4 (0.40) | HSD17B10TSHRHPGDCYP3A4HSP90AA1 | |
| SCHEMBL23409587 | 0.70 | HSD17B10 (0.38) | HSD17B10TSHRHPGDCYP3A4HSP90AA1 | |
| SCHEMBL29970962 | 0.70 | HSD17B10 (0.38) | HSD17B10TSHRHPGDCYP3A4HSP90AA1 | |
| SCHEMBL516276 | 0.70 | CA9 (0.37) | HSD17B10ALDH1A1MAPK1TDP1ALOX15 | |
| SCHEMBL202648 | 0.69 | HSD17B10 (1.00) | HSD17B10TSHRHPGDCYP3A4HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6436961-B1 | SUBSTANCE P RECEPTOR ANTAGONIST; 2-PHENYL-3-BENZYLAMINOPIPERIDINES | PFIZER INC | 2002-08-20 | — | — | US | disclosed |
| EP-0700384-A1 | PROCESS FOR PREPARING AND RESOLVING 2-PHENYL-3-AMINOPIPERIDINE | PFIZER (US) | 1996-03-13 | — | — | EP | disclosed |
| WO-1994027966-A1 | PROCESS FOR PREPARING AND RESOLVING 2-PHENYL-3-AMINOPIPERIDINE | PFIZER INC. (US) | 1994-12-08 | — | — | WO | disclosed |
| US-4020112-A | WITH SULFUR TETRAFLUORIDE IN HYDROGEN FLUORIDE | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1977-04-26 | — | — | US | disclosed |