Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRF1 | P14222 | 3/20 | 0.44 |
| ▸ | GRM5 | P41594 | 3/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD5 | P21918 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | LPL | P06858 | 2/20 | 0.36 |
| ▸ | LIPG | Q9Y5X9 | 2/20 | 0.36 |
| ▸ | IDH1 | O75874 | 1/20 | 0.35 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29956413 | 0.92 | LMNA (0.42) | PRF1GRM5HDAC6KDM4EALOX15 | |
| SCHEMBL29955396 | 0.86 | PRF1 (0.40) | PRF1GRM5HDAC6KDM4EALOX15 | |
| SCHEMBL2559421 | 0.85 | PRF1 (0.43) | PRF1HDAC6KDM4EALOX15TSHR | |
| SCHEMBL2499130 | 0.82 | GRM5 (0.46) | PRF1GRM5HDAC6KDM4EALOX15 | |
| SCHEMBL29956886 | 0.81 | ALDH1A1 (0.42) | PRF1GRM5KDM4EALOX15TSHR | |
| SCHEMBL2627975 | 0.79 | PARP1 (0.47) | HDAC6KDM4EALOX15TSHRSIRT1 | |
| SCHEMBL2504791 | 0.79 | KDM4E (0.52) | PRF1GRM5HDAC6KDM4EALOX15 | |
| SCHEMBL2504781 | 0.79 | GRM5 (0.46) | PRF1GRM5HDAC6KDM4EALOX15 | |
| SCHEMBL289469 | 0.78 | UGCG (0.39) | PRF1GRM5PARP1 | |
| SCHEMBL29431366 | 0.78 | UGCG (0.39) | PRF1GRM5PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8314120-B2 | Small molecule potentiators of metabotropic glutamate receptors | ABBOTT GMBH & CO. KG (DE) | 2012-11-20 | — | — | US | disclosed |
| US-20110245247-A1 | NOVEL SMALL MOLECULE POTENTIATORS OF METABOTROPIC GLUTAMATE RECEPTORS | ABBOTT GMBH & CO. KG (DE) | 2011-10-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110245247-A1 | NOVEL SMALL MOLECULE POTENTIATORS OF METABOTROPIC GLUTAMATE RECEPTORS | GRIN2C, GRM3, GRM2 | PRF1 4486/4885GRM5 18/4885HDAC6 2622/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.