Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 17/20 | 0.39 |
| ▸ | SOS1 | Q07889 | 4/20 | 0.39 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25021516 | 0.93 | KRAS (0.39) | KRASSOS1CHRNB1CHRNB2CHRNB4 | |
| SCHEMBL25021052 | 0.93 | KRAS (0.39) | KRASSOS1CHRNB1CHRNB2CHRNB4 | |
| SCHEMBL23156819 | 0.80 | KRAS (0.45) | KRASSOS1 | |
| SCHEMBL23156751 | 0.80 | KRAS (0.45) | KRASSOS1 | |
| SCHEMBL21005734 | 0.79 | KRAS (0.47) | KRASSOS1 | |
| SCHEMBL23481644 | 0.79 | KRAS (0.45) | KRASSOS1 | |
| SCHEMBL28997244 | 0.77 | KRAS (0.46) | KRASSOS1 | |
| SCHEMBL28997241 | 0.77 | KRAS (0.46) | KRASSOS1 | |
| SCHEMBL26947438 | 0.77 | KRAS (0.53) | KRAS | |
| SCHEMBL28589813 | 0.75 | KRAS (0.48) | KRASSOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3710439-B1 | KRAS G12C INHIBITORS | MIRATI THERAPEUTICS INC (US) | 2023-02-15 | — | — | EP | disclosed |