Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 2/20 | 0.30 |
| ▸ | MAOB | P27338 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30184645 | 1.00 | MAOA (0.30) | MAOAMAOB | |
| SCHEMBL25030921 | 0.84 | MAPT (0.31) | — | |
| SCHEMBL25033451 | 0.80 | SMN1; SMN2 (0.34) | — | |
| SCHEMBL25033427 | 0.78 | MAOA (0.35) | MAOAMAOB | |
| SCHEMBL30184453 | 0.77 | ALDH1A1 (0.33) | — | |
| SCHEMBL25033103 | 0.77 | ALDH1A1 (0.33) | — | |
| SCHEMBL25033063 | 0.75 | INSR (0.41) | MAOA | |
| SCHEMBL30871276 | 0.75 | INSR (0.41) | MAOA | |
| SCHEMBL25033172 | 0.75 | RECQL (0.34) | — | |
| SCHEMBL30184488 | 0.75 | INSR (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4676602-A1 | COMPOUNDS TARGETING MUTATIONS IN P53 AND USES THEREOF | Merck Sharp & Dohme LLC (US) | 2026-01-14 | — | — | EP | disclosed |
| WO-2024187153-A1 | COMPOUNDS TARGETING MUTATIONS IN P53 AND USES THEREOF | MERCK SHARP & DOHME LLC (US) | 2024-09-12 | — | — | WO | disclosed |
| CN-117813295-A | Compounds targeting p53 mutants | 北京加科思新药研发有限公司 | 2024-04-02 | — | — | CN | disclosed |
| WO-2023016434-A1 | COMPOUNDS TARGETING MUTANT OF P53 | JACOBIO PHARMACEUTICALS CO., LTD. (CN) | 2023-02-16 | — | — | WO | disclosed |