Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 11/20 | 1.00 |
| ▸ | KIT | P10721 | 1/20 | 0.64 |
| ▸ | FLT4 | P35916 | 1/20 | 0.64 |
| ▸ | KDR | P35968 | 1/20 | 0.64 |
| ▸ | FLT3 | P36888 | 1/20 | 0.64 |
| ▸ | MEN1 | O00255 | 3/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | PPARG | P37231 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | CLK1 | P49759 | 1/20 | 0.49 |
| ▸ | GSK3B | P49841 | 1/20 | 0.49 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17537613 | 0.80 | PDGFRB (0.66) | PDGFRBKITFLT4KDRFLT3 | |
| SCHEMBL1902587 | 0.77 | MEN1 (1.00) | PDGFRBMEN1KMT2AALDH1A1MAPT | |
| Nortopsentin D SCHEMBL29489921 | 0.77 | PDGFRB (0.62) | PDGFRBMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL13624863 | 0.76 | PDGFRB (0.60) | PDGFRBKITFLT4KDRFLT3 | |
| SCHEMBL4398433 | 0.76 | MAPT (0.62) | PDGFRBMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL25034150 | 0.74 | TUBB4A (0.68) | PDGFRBMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL25034155 | 0.73 | PDGFRB (0.57) | PDGFRBMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL4400158 | 0.72 | PDGFRB (0.56) | PDGFRBKITFLT4KDRFLT3 | |
| SCHEMBL25034156 | 0.71 | MAPT (0.57) | PDGFRBKDRMEN1KMT2AALDH1A1 | |
| SCHEMBL1202543 | 0.71 | IMPDH2 (0.63) | MEN1KMT2AALDH1A1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023018747-A1 | INHIBITORS OF HYPOXIA-INDUCIBLE FACTORS | THE JOHNS HOPKINS UNIVERSITY (US) | 2023-02-16 | — | — | WO | disclosed |