Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 9/20 | 0.46 |
| ▸ | DRD3 | P35462 | 9/20 | 0.46 |
| ▸ | DRD4 | P21917 | 8/20 | 0.46 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.43 |
| ▸ | P2RY12 | Q9H244 | 2/20 | 0.43 |
| ▸ | DHFR | P00374 | 1/20 | 0.42 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30475449 | 1.00 | DRD2 (0.46) | DRD2DRD3DRD4PDE3BPDE3A | |
| SCHEMBL25033932 | 0.92 | DRD2 (0.49) | DRD2DRD3DRD4PDE3BPDE3A | |
| SCHEMBL31213546 | 0.88 | DDB1 (0.44) | DRD2DRD3DRD4DDB1CRBN | |
| SCHEMBL25035194 | 0.84 | ALDH1A1 (0.42) | DRD2DRD3DRD4PDE3BPDE3A | |
| SCHEMBL30475454 | 0.84 | ALDH1A1 (0.42) | DRD2DRD3DRD4PDE3BPDE3A | |
| SCHEMBL30671540 | 0.80 | DDB1 (0.42) | DHFRDDB1CRBN | |
| SCHEMBL26699625 | 0.80 | DDB1 (0.42) | DHFRDDB1CRBN | |
| SCHEMBL29386236 | 0.77 | KDM4E (0.50) | PDE3BPDE3ADDB1CRBN | |
| SCHEMBL21408886 | 0.77 | KDM4E (0.50) | PDE3BPDE3ADDB1CRBN | |
| SCHEMBL24735334 | 0.77 | KMT2A (0.48) | DRD2DRD3DRD4PDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023017446-A1 | NOVEL PLK1 DEGRADATION INDUCING COMPOUND | UPPTHERA, INC. (KR) | 2023-02-16 | — | — | WO | disclosed |
| WO-2023018238-A1 | NOVEL PLK1 DEGRADATION INDUCING COMPOUND | UPPTHERA, INC. (KR) | 2023-02-16 | — | — | WO | disclosed |